Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA)
Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck (Piperaceae) is a medicinal plant traditionally used in Brazil to treat infectious diseases. The extracts obtained of the leaves from P. regnellii were investigated for their antibacterial activities against methicillin-resistant Staphyloc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/4/2060/ |
| _version_ | 1818807692241666048 |
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| author | Benedito Prado Dias Filho Celso Vataru Nakamura Tânia Ueda-Nakamura Diógenes Aparício Garcia Cortez Flaviano João Basilio Marçal |
| author_facet | Benedito Prado Dias Filho Celso Vataru Nakamura Tânia Ueda-Nakamura Diógenes Aparício Garcia Cortez Flaviano João Basilio Marçal |
| author_sort | Benedito Prado Dias Filho |
| collection | DOAJ |
| description | Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck (Piperaceae) is a medicinal plant traditionally used in Brazil to treat infectious diseases. The extracts obtained of the leaves from P. regnellii were investigated for their antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). The ethyl acetate extract presented a good activity against MRSA, with minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 16 μg/mL. Based on this finding, the ethyl acetate extract was fractionated by silica gel column chromatography into nine fractions. The hexane fraction was active against MRSA (MIC at 4 μg/mL). Further column chromatography separation of the hexane fraction afforded the pure compound eupomatenoid-5. The structure of the compound was established by spectral data (1H and 13C NMR HSQC, HMBC, gNOE, IR and MS). Eupomatenoid-5 was the only compound active on the bacterium. The antibacterial property of P. regnellii extract provides preliminary scientific validation for the traditional medicinal use of this plant. The active compound eupomatenoid-5 should be further studied in animal models to verify in vivo efficacy and toxicity. |
| first_indexed | 2024-12-18T19:29:42Z |
| format | Article |
| id | doaj.art-066471e660eb409cb059c33627e25184 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T19:29:42Z |
| publishDate | 2010-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-066471e660eb409cb059c33627e251842022-12-21T20:55:46ZengMDPI AGMolecules1420-30492010-03-011542060206910.3390/molecules15042060Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA)Benedito Prado Dias FilhoCelso Vataru NakamuraTânia Ueda-NakamuraDiógenes Aparício Garcia CortezFlaviano João Basilio MarçalPiper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck (Piperaceae) is a medicinal plant traditionally used in Brazil to treat infectious diseases. The extracts obtained of the leaves from P. regnellii were investigated for their antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). The ethyl acetate extract presented a good activity against MRSA, with minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 16 μg/mL. Based on this finding, the ethyl acetate extract was fractionated by silica gel column chromatography into nine fractions. The hexane fraction was active against MRSA (MIC at 4 μg/mL). Further column chromatography separation of the hexane fraction afforded the pure compound eupomatenoid-5. The structure of the compound was established by spectral data (1H and 13C NMR HSQC, HMBC, gNOE, IR and MS). Eupomatenoid-5 was the only compound active on the bacterium. The antibacterial property of P. regnellii extract provides preliminary scientific validation for the traditional medicinal use of this plant. The active compound eupomatenoid-5 should be further studied in animal models to verify in vivo efficacy and toxicity.http://www.mdpi.com/1420-3049/15/4/2060/Piper regnelliiStaphylococcus aureusneolignansMRSAantibacterial activity |
| spellingShingle | Benedito Prado Dias Filho Celso Vataru Nakamura Tânia Ueda-Nakamura Diógenes Aparício Garcia Cortez Flaviano João Basilio Marçal Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA) Molecules Piper regnellii Staphylococcus aureus neolignans MRSA antibacterial activity |
| title | Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_full | Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_fullStr | Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_full_unstemmed | Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_short | Activity of the Extracts and Neolignans from Piper regnellii against Methicillin-Resistant Staphylococcus aureus (MRSA) |
| title_sort | activity of the extracts and neolignans from piper regnellii against methicillin resistant staphylococcus aureus mrsa |
| topic | Piper regnellii Staphylococcus aureus neolignans MRSA antibacterial activity |
| url | http://www.mdpi.com/1420-3049/15/4/2060/ |
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