2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide
Herein, we report the synthesis of 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide in the reaction between 7-amino-4-methyl-2<i>H</i>-chromen-2-one and (±)-flurbiprofen. The newly-obtained bio-functional hybrid compoun...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2023/3/M1682 |
| _version_ | 1797578645688025088 |
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| author | Stanimir Manolov Iliyan Ivanov Dimitar Bojilov Paraskev Nedialkov |
| author_facet | Stanimir Manolov Iliyan Ivanov Dimitar Bojilov Paraskev Nedialkov |
| author_sort | Stanimir Manolov |
| collection | DOAJ |
| description | Herein, we report the synthesis of 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide in the reaction between 7-amino-4-methyl-2<i>H</i>-chromen-2-one and (±)-flurbiprofen. The newly-obtained bio-functional hybrid compound was fully characterized via <sup>1</sup>H, <sup>13</sup>C NMR, UV, and mass spectral data. |
| first_indexed | 2024-03-10T22:25:44Z |
| format | Article |
| id | doaj.art-066753e063974d7f8df0987070efdf39 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T22:25:44Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-066753e063974d7f8df0987070efdf392023-11-19T12:06:34ZengMDPI AGMolbank1422-85992023-07-0120233M168210.3390/M16822-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamideStanimir Manolov0Iliyan Ivanov1Dimitar Bojilov2Paraskev Nedialkov3Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, BulgariaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, BulgariaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, BulgariaDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, BulgariaHerein, we report the synthesis of 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide in the reaction between 7-amino-4-methyl-2<i>H</i>-chromen-2-one and (±)-flurbiprofen. The newly-obtained bio-functional hybrid compound was fully characterized via <sup>1</sup>H, <sup>13</sup>C NMR, UV, and mass spectral data.https://www.mdpi.com/1422-8599/2023/3/M16827-amino-4-methyl-coumarin(±)-flurbiprofenamide |
| spellingShingle | Stanimir Manolov Iliyan Ivanov Dimitar Bojilov Paraskev Nedialkov 2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide Molbank 7-amino-4-methyl-coumarin (±)-flurbiprofen amide |
| title | 2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide |
| title_full | 2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide |
| title_fullStr | 2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide |
| title_full_unstemmed | 2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide |
| title_short | 2-(2-Fluoro-[1,1′-biphenyl]-4-yl)-<i>N</i>-(4-methyl-2-oxo-2<i>H</i>-chromen-7-yl)propanamide |
| title_sort | 2 2 fluoro 1 1 biphenyl 4 yl i n i 4 methyl 2 oxo 2 i h i chromen 7 yl propanamide |
| topic | 7-amino-4-methyl-coumarin (±)-flurbiprofen amide |
| url | https://www.mdpi.com/1422-8599/2023/3/M1682 |
| work_keys_str_mv | AT stanimirmanolov 22fluoro11biphenyl4ylini4methyl2oxo2ihichromen7ylpropanamide AT iliyanivanov 22fluoro11biphenyl4ylini4methyl2oxo2ihichromen7ylpropanamide AT dimitarbojilov 22fluoro11biphenyl4ylini4methyl2oxo2ihichromen7ylpropanamide AT paraskevnedialkov 22fluoro11biphenyl4ylini4methyl2oxo2ihichromen7ylpropanamide |