Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital
ABSTRACT Tuberculosis continues to be a major public health problem worldwide. The aim of the present study was to evaluate the accuracy of the Xpert MTB/RIF rapid molecular test for tuberculosis, using pulmonary samples obtained from patients treated at the Júlia Kubitschek Hospital, which is opera...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
2019-03-01
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| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200300&lng=en&tlng=en |
| _version_ | 1818204206557822976 |
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| author | Tatiane Maria da Silva Valéria Martins Soares Mariana Gontijo Ramos Adriana dos Santos |
| author_facet | Tatiane Maria da Silva Valéria Martins Soares Mariana Gontijo Ramos Adriana dos Santos |
| author_sort | Tatiane Maria da Silva |
| collection | DOAJ |
| description | ABSTRACT Tuberculosis continues to be a major public health problem worldwide. The aim of the present study was to evaluate the accuracy of the Xpert MTB/RIF rapid molecular test for tuberculosis, using pulmonary samples obtained from patients treated at the Júlia Kubitschek Hospital, which is operated by the Hospital Foundation of the State of Minas Gerais, in the city of Belo Horizonte, Brazil. This was a retrospective study comparing the Xpert MTB/RIF test results with those of standard culture for Mycobacterium tuberculosis and phenotypic susceptibility tests. Although the Xpert MTB/RIF test showed high accuracy for the detection of M. tuberculosis and its resistance to rifampin, attention must be given to the clinical status of the patient, in relation to the test results, as well as to the limitations of molecular tests. |
| first_indexed | 2024-12-12T03:37:33Z |
| format | Article |
| id | doaj.art-0667f1a8460c474f8fbe16bf6d036779 |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-12-12T03:37:33Z |
| publishDate | 2019-03-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-0667f1a8460c474f8fbe16bf6d0367792022-12-22T00:39:45ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562019-03-0145210.1590/1806-3713/e20170451S1806-37132019000200300Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospitalTatiane Maria da SilvaValéria Martins SoaresMariana Gontijo RamosAdriana dos SantosABSTRACT Tuberculosis continues to be a major public health problem worldwide. The aim of the present study was to evaluate the accuracy of the Xpert MTB/RIF rapid molecular test for tuberculosis, using pulmonary samples obtained from patients treated at the Júlia Kubitschek Hospital, which is operated by the Hospital Foundation of the State of Minas Gerais, in the city of Belo Horizonte, Brazil. This was a retrospective study comparing the Xpert MTB/RIF test results with those of standard culture for Mycobacterium tuberculosis and phenotypic susceptibility tests. Although the Xpert MTB/RIF test showed high accuracy for the detection of M. tuberculosis and its resistance to rifampin, attention must be given to the clinical status of the patient, in relation to the test results, as well as to the limitations of molecular tests.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200300&lng=en&tlng=enTuberculosis/diagnosisMolecular diagnostic techniquesSputumBronchoalveolar lavage fluid |
| spellingShingle | Tatiane Maria da Silva Valéria Martins Soares Mariana Gontijo Ramos Adriana dos Santos Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital Jornal Brasileiro de Pneumologia Tuberculosis/diagnosis Molecular diagnostic techniques Sputum Bronchoalveolar lavage fluid |
| title | Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital |
| title_full | Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital |
| title_fullStr | Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital |
| title_full_unstemmed | Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital |
| title_short | Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital |
| title_sort | accuracy of a rapid molecular test for tuberculosis in sputum samples bronchoalveolar lavage fluid and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital |
| topic | Tuberculosis/diagnosis Molecular diagnostic techniques Sputum Bronchoalveolar lavage fluid |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200300&lng=en&tlng=en |
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