Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism
As of November 2022, 22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore, the researchers have proposed hypotheses about the possible etiological hypothesis of these...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Army Medical University
2023-03-01
|
| Series: | 陆军军医大学学报 |
| Subjects: | |
| Online Access: | http://aammt.tmmu.edu.cn/html/202211036.htm |
| _version_ | 1797869947618066432 |
|---|---|
| author | DENG Guohong SHI Tuo |
| author_facet | DENG Guohong SHI Tuo |
| author_sort | DENG Guohong |
| collection | DOAJ |
| description | As of November 2022, 22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore, the researchers have proposed hypotheses about the possible etiological hypothesis of these 2 pathogens, but the existing test results cannot clarify the specific etiology and pathogenic mechanism yet. In this article, we aims to analyze the plausible pathogenic mechanism from the perspective of etiology and immunopathology in order to provide ideas for investigating the pathogenic mechanism.
|
| first_indexed | 2024-04-10T00:19:29Z |
| format | Article |
| id | doaj.art-06682c1c23404003ab756a04eb3f77ba |
| institution | Directory Open Access Journal |
| issn | 2097-0927 |
| language | zho |
| last_indexed | 2024-04-10T00:19:29Z |
| publishDate | 2023-03-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj.art-06682c1c23404003ab756a04eb3f77ba2023-03-16T02:30:20ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272023-03-0145537337910.16016/j.2097-0927.202211036Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanismDENG Guohong0 SHI Tuo 1Department of Infectious Diseases, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaDepartment of Infectious Diseases, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaAs of November 2022, 22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore, the researchers have proposed hypotheses about the possible etiological hypothesis of these 2 pathogens, but the existing test results cannot clarify the specific etiology and pathogenic mechanism yet. In this article, we aims to analyze the plausible pathogenic mechanism from the perspective of etiology and immunopathology in order to provide ideas for investigating the pathogenic mechanism. http://aammt.tmmu.edu.cn/html/202211036.htmchildrenunknown cause severe acute hepatitispathogenic mechanismadenovirustissue tropismsuperantigengenetic predisposition |
| spellingShingle | DENG Guohong SHI Tuo Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism 陆军军医大学学报 children unknown cause severe acute hepatitis pathogenic mechanism adenovirus tissue tropism superantigen genetic predisposition |
| title | Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism |
| title_full | Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism |
| title_fullStr | Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism |
| title_full_unstemmed | Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism |
| title_short | Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism |
| title_sort | outbreak of severe acute hepatitis of unknown cause in children in 2022 analysis of plausible pathogenic mechanism |
| topic | children unknown cause severe acute hepatitis pathogenic mechanism adenovirus tissue tropism superantigen genetic predisposition |
| url | http://aammt.tmmu.edu.cn/html/202211036.htm |
| work_keys_str_mv | AT dengguohong outbreakofsevereacutehepatitisofunknowncauseinchildrenin2022analysisofplausiblepathogenicmechanism AT shituo outbreakofsevereacutehepatitisofunknowncauseinchildrenin2022analysisofplausiblepathogenicmechanism |