Protective effects of acerola juice on genotoxicity induced by iron in vivo
Abstract Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to B...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2016-03-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000100122&lng=en&tlng=en |
| _version_ | 1818510562439462912 |
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| author | Roberta Nunes Horta Vivian Francilia Silva Kahl Merielen da Silva Sarmento Marisa Fernanda Silva Nunes Carem Rejane Maglione Porto Vanessa Moraes de Andrade Alexandre de Barros Falcão Ferraz Juliana Da Silva |
| author_facet | Roberta Nunes Horta Vivian Francilia Silva Kahl Merielen da Silva Sarmento Marisa Fernanda Silva Nunes Carem Rejane Maglione Porto Vanessa Moraes de Andrade Alexandre de Barros Falcão Ferraz Juliana Da Silva |
| author_sort | Roberta Nunes Horta |
| collection | DOAJ |
| description | Abstract Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Acerola is considered a functional fruit due to its high antioxidant properties and phenolic contents, and therefore is consumed to prevent diseases or as adjuvant in treatment strategies. Here, the influence of ripe and unripe acerola juices on iron genotoxicity was analyzed in vivo using the comet assay and micronucleus test. The comet assay results showed that acerola juice exerted no genotoxic or antigenotoxic activity. Neither ripe nor unripe acerola juices were mutagenic to animals treated with juices, in micronucleus test. However, when compared to iron group, the pre-treatment with acerola juices exerted antimutagenic activity, decreasing significantly micronucleus mean values in bone marrow. Stage of ripeness did not influence the interaction of acerola compounds with DNA, and both ripe and unripe acerola juices exerted protective effect over DNA damage generated by iron. |
| first_indexed | 2024-12-10T23:21:38Z |
| format | Article |
| id | doaj.art-06685c6228264e0fb87a92af54465df7 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-10T23:21:38Z |
| publishDate | 2016-03-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-06685c6228264e0fb87a92af54465df72022-12-22T01:29:41ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852016-03-0139112212810.1590/1678-4685-GMB-2015-0157S1415-47572016000100122Protective effects of acerola juice on genotoxicity induced by iron in vivoRoberta Nunes HortaVivian Francilia Silva KahlMerielen da Silva SarmentoMarisa Fernanda Silva NunesCarem Rejane Maglione PortoVanessa Moraes de AndradeAlexandre de Barros Falcão FerrazJuliana Da SilvaAbstract Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Acerola is considered a functional fruit due to its high antioxidant properties and phenolic contents, and therefore is consumed to prevent diseases or as adjuvant in treatment strategies. Here, the influence of ripe and unripe acerola juices on iron genotoxicity was analyzed in vivo using the comet assay and micronucleus test. The comet assay results showed that acerola juice exerted no genotoxic or antigenotoxic activity. Neither ripe nor unripe acerola juices were mutagenic to animals treated with juices, in micronucleus test. However, when compared to iron group, the pre-treatment with acerola juices exerted antimutagenic activity, decreasing significantly micronucleus mean values in bone marrow. Stage of ripeness did not influence the interaction of acerola compounds with DNA, and both ripe and unripe acerola juices exerted protective effect over DNA damage generated by iron.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000100122&lng=en&tlng=engenotoxicitycomet assaymicronucleusacerola juiceiron |
| spellingShingle | Roberta Nunes Horta Vivian Francilia Silva Kahl Merielen da Silva Sarmento Marisa Fernanda Silva Nunes Carem Rejane Maglione Porto Vanessa Moraes de Andrade Alexandre de Barros Falcão Ferraz Juliana Da Silva Protective effects of acerola juice on genotoxicity induced by iron in vivo Genetics and Molecular Biology genotoxicity comet assay micronucleus acerola juice iron |
| title | Protective effects of acerola juice on genotoxicity induced by iron in vivo |
| title_full | Protective effects of acerola juice on genotoxicity induced by iron in vivo |
| title_fullStr | Protective effects of acerola juice on genotoxicity induced by iron in vivo |
| title_full_unstemmed | Protective effects of acerola juice on genotoxicity induced by iron in vivo |
| title_short | Protective effects of acerola juice on genotoxicity induced by iron in vivo |
| title_sort | protective effects of acerola juice on genotoxicity induced by iron in vivo |
| topic | genotoxicity comet assay micronucleus acerola juice iron |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000100122&lng=en&tlng=en |
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