Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets
Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggres...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/1/148 |
| _version_ | 1811283174572949504 |
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| author | Annie Schmid-Alliana Heidy Schmid-Antomarchi Rasha Al-Sahlanee Patricia Lagadec Jean-Claude Scimeca Elise Verron |
| author_facet | Annie Schmid-Alliana Heidy Schmid-Antomarchi Rasha Al-Sahlanee Patricia Lagadec Jean-Claude Scimeca Elise Verron |
| author_sort | Annie Schmid-Alliana |
| collection | DOAJ |
| description | Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue. Lastly, we detail therapies for bone metastases. Due to poor prognosis for patients, the strategies mainly aim at reducing the impact of skeletal-related events on patients’ quality of life. However, recent advances have led to a better understanding of molecular mechanisms underlying bone metastases progression, and therefore of novel therapeutic targets. |
| first_indexed | 2024-04-13T02:06:44Z |
| format | Article |
| id | doaj.art-0669f69d7f4946baa208c61fb0f1d5be |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T02:06:44Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0669f69d7f4946baa208c61fb0f1d5be2022-12-22T03:07:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-01-0119114810.3390/ijms19010148ijms19010148Understanding the Progression of Bone Metastases to Identify Novel Therapeutic TargetsAnnie Schmid-Alliana0Heidy Schmid-Antomarchi1Rasha Al-Sahlanee2Patricia Lagadec3Jean-Claude Scimeca4Elise Verron5Centre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, Inserm, iBV, 06108 Nice, FranceCentre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, Inserm, iBV, 06108 Nice, FranceCentre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, Inserm, iBV, 06108 Nice, FranceCentre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, Inserm, iBV, 06108 Nice, FranceCentre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, Inserm, iBV, 06108 Nice, FranceRegenerative Medicine and Skeleton. RMeS-Lab, INSERM UMR 1229, University of Nantes, 44000 Nantes, FranceBone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue. Lastly, we detail therapies for bone metastases. Due to poor prognosis for patients, the strategies mainly aim at reducing the impact of skeletal-related events on patients’ quality of life. However, recent advances have led to a better understanding of molecular mechanisms underlying bone metastases progression, and therefore of novel therapeutic targets.http://www.mdpi.com/1422-0067/19/1/148bone metastasesbone tropismbone microenvironmentmolecular mechanismstherapeutic strategies |
| spellingShingle | Annie Schmid-Alliana Heidy Schmid-Antomarchi Rasha Al-Sahlanee Patricia Lagadec Jean-Claude Scimeca Elise Verron Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets International Journal of Molecular Sciences bone metastases bone tropism bone microenvironment molecular mechanisms therapeutic strategies |
| title | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
| title_full | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
| title_fullStr | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
| title_full_unstemmed | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
| title_short | Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets |
| title_sort | understanding the progression of bone metastases to identify novel therapeutic targets |
| topic | bone metastases bone tropism bone microenvironment molecular mechanisms therapeutic strategies |
| url | http://www.mdpi.com/1422-0067/19/1/148 |
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