Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease
Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1331575/full |
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| author | Banashree Mondal Supriyo Choudhury Rebecca Banerjee Akash Roy Koustav Chatterjee Purba Basu Ravi Singh Saptak Halder Shantanu Shubham Stuart N. Baker Mark R. Baker Mark R. Baker Mark R. Baker Hrishikesh Kumar |
| author_facet | Banashree Mondal Supriyo Choudhury Rebecca Banerjee Akash Roy Koustav Chatterjee Purba Basu Ravi Singh Saptak Halder Shantanu Shubham Stuart N. Baker Mark R. Baker Mark R. Baker Mark R. Baker Hrishikesh Kumar |
| author_sort | Banashree Mondal |
| collection | DOAJ |
| description | Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson’s disease (PD) patients. In a subgroup of patients, we measured selected neurotrophins, inflammatory markers and markers of oxidative stress in serum. Thirty-three PD patients with freezing of gait (FOG) were randomized to either active nVNS or sham nVNS. After baseline assessments, patients were instructed to deliver six 2 min stimulations (12 min/day) of the active nVNS/sham nVNS device for 1 month at home. Patients were then re-assessed. After a one-month washout period, they were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters (speed, stance time and step length) were observed with active nVNS. While serum tumor necrosis factor- α decreased, glutathione and brain-derived neurotrophic factor levels increased significantly (p < 0.05) after active nVNS treatment. Here we present the first evidence of the efficacy and safety of nVNS in the treatment of gait in PD patients, and propose that nVNS can be used as an adjunctive therapy in the management of PD patients, especially those suffering from FOG.Clinical trial registration: identifier ISRCTN14797144. |
| first_indexed | 2024-03-08T05:13:46Z |
| format | Article |
| id | doaj.art-066abd10196d414085505ddb9231bb58 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-08T05:13:46Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-066abd10196d414085505ddb9231bb582024-02-07T04:42:45ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-02-011510.3389/fnagi.2023.13315751331575Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s diseaseBanashree Mondal0Supriyo Choudhury1Rebecca Banerjee2Akash Roy3Koustav Chatterjee4Purba Basu5Ravi Singh6Saptak Halder7Shantanu Shubham8Stuart N. Baker9Mark R. Baker10Mark R. Baker11Mark R. Baker12Hrishikesh Kumar13Institute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaInstitute of Neurosciences Kolkata, Kolkata, IndiaFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United KingdomFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United KingdomDepartment of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne, United KingdomDepartment of Clinical Neurophysiology, Royal Victoria Infirmary, Newcastle upon Tyne, United KingdomInstitute of Neurosciences Kolkata, Kolkata, IndiaNon-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson’s disease (PD) patients. In a subgroup of patients, we measured selected neurotrophins, inflammatory markers and markers of oxidative stress in serum. Thirty-three PD patients with freezing of gait (FOG) were randomized to either active nVNS or sham nVNS. After baseline assessments, patients were instructed to deliver six 2 min stimulations (12 min/day) of the active nVNS/sham nVNS device for 1 month at home. Patients were then re-assessed. After a one-month washout period, they were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters (speed, stance time and step length) were observed with active nVNS. While serum tumor necrosis factor- α decreased, glutathione and brain-derived neurotrophic factor levels increased significantly (p < 0.05) after active nVNS treatment. Here we present the first evidence of the efficacy and safety of nVNS in the treatment of gait in PD patients, and propose that nVNS can be used as an adjunctive therapy in the management of PD patients, especially those suffering from FOG.Clinical trial registration: identifier ISRCTN14797144.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1331575/fullvagus nerve stimulationParkinson’s diseasegaitneuroinflammationoxidative stress |
| spellingShingle | Banashree Mondal Supriyo Choudhury Rebecca Banerjee Akash Roy Koustav Chatterjee Purba Basu Ravi Singh Saptak Halder Shantanu Shubham Stuart N. Baker Mark R. Baker Mark R. Baker Mark R. Baker Hrishikesh Kumar Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease Frontiers in Aging Neuroscience vagus nerve stimulation Parkinson’s disease gait neuroinflammation oxidative stress |
| title | Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease |
| title_full | Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease |
| title_fullStr | Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease |
| title_full_unstemmed | Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease |
| title_short | Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease |
| title_sort | effects of non invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in parkinson s disease |
| topic | vagus nerve stimulation Parkinson’s disease gait neuroinflammation oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1331575/full |
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