Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021
Summary: Background: Vietnam has one of the highest rates of antibiotic resistance in Asia. In 2020, the Vietnam Minister of Health introduced new legislation for the implementation of an antimicrobial stewardship program (ASP). The evidence for the effectiveness of ASP in small hospitals and hospi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Infection Prevention in Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590088923000446 |
| _version_ | 1827592899889463296 |
|---|---|
| author | Hai-Yen Nguyen-Thi Tran Viet Bui Hong-Nguyen Tran-Thi Anh Dang Minh Le Bao Dang Gia Nguyen Hong-Nhung Tran-Thi Thien Nguyen Nguyen Dang Tu Le |
| author_facet | Hai-Yen Nguyen-Thi Tran Viet Bui Hong-Nguyen Tran-Thi Anh Dang Minh Le Bao Dang Gia Nguyen Hong-Nhung Tran-Thi Thien Nguyen Nguyen Dang Tu Le |
| author_sort | Hai-Yen Nguyen-Thi |
| collection | DOAJ |
| description | Summary: Background: Vietnam has one of the highest rates of antibiotic resistance in Asia. In 2020, the Vietnam Minister of Health introduced new legislation for the implementation of an antimicrobial stewardship program (ASP). The evidence for the effectiveness of ASP in small hospitals and hospitals located in provinces was limited compared with larger-scale and central city hospitals. Aim: Evaluation of the impact before and after the introduction of an antimicrobial stewardship program at Dong Thap General Hospital, from 2017 to 2021. Methods: Retrospective data was collected from June 2017 to June 2021. The impact of the ASP on changes in antibiotic use and the clinical outcome associated with the implementation of the ASP was evaluated using autoregressive integrated moving average modelling of controlled interrupted time-series analysis. Results: There was a significant and sustained decrease in antibiotic consumption level (step change) in 2 indicators, DOT/1000PD (129.55; P<0.01) and LOT/1000PD (99.95, P<0.01), immediately after the ASP intervention. There were no statistically significant changes identified in terms of consumption with DDD/1000PD, or in the clinical outcomes. The results showed no statistically significant change in consumption trend (ramps) in all evaluated indicators. No statistically significant changes in consumption levels and trends were observed in the control group. Conclusion: The ASP implemented in Dong Thap General Hospital from 2017 to 2021 showed a considerable influence on antibiotic consumption as indicated by the DOT/1000 PD and LOT/1000 PD during the initial stages. Moreover, controlling antibiotic consumption did not negatively impact patient outcomes. |
| first_indexed | 2024-03-09T02:01:24Z |
| format | Article |
| id | doaj.art-066abfbd6e214007a1ff07e71158efc6 |
| institution | Directory Open Access Journal |
| issn | 2590-0889 |
| language | English |
| last_indexed | 2024-03-09T02:01:24Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infection Prevention in Practice |
| spelling | doaj.art-066abfbd6e214007a1ff07e71158efc62023-12-08T04:45:58ZengElsevierInfection Prevention in Practice2590-08892023-12-0154100311Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021Hai-Yen Nguyen-Thi0Tran Viet Bui1Hong-Nguyen Tran-Thi2Anh Dang Minh Le3Bao Dang Gia Nguyen4Hong-Nhung Tran-Thi5Thien Nguyen6Nguyen Dang Tu Le7Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, VietnamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, VietnamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, VietnamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, VietnamBlackett Laboratory, Imperial College London, London, United KingdomFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, VietnamDepartment of Pharmacy, Dong Thap General Hospital, Cao Lanh City, VietnamFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, Vietnam; Corresponding author. Address: Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, 70000, Vietnam.Summary: Background: Vietnam has one of the highest rates of antibiotic resistance in Asia. In 2020, the Vietnam Minister of Health introduced new legislation for the implementation of an antimicrobial stewardship program (ASP). The evidence for the effectiveness of ASP in small hospitals and hospitals located in provinces was limited compared with larger-scale and central city hospitals. Aim: Evaluation of the impact before and after the introduction of an antimicrobial stewardship program at Dong Thap General Hospital, from 2017 to 2021. Methods: Retrospective data was collected from June 2017 to June 2021. The impact of the ASP on changes in antibiotic use and the clinical outcome associated with the implementation of the ASP was evaluated using autoregressive integrated moving average modelling of controlled interrupted time-series analysis. Results: There was a significant and sustained decrease in antibiotic consumption level (step change) in 2 indicators, DOT/1000PD (129.55; P<0.01) and LOT/1000PD (99.95, P<0.01), immediately after the ASP intervention. There were no statistically significant changes identified in terms of consumption with DDD/1000PD, or in the clinical outcomes. The results showed no statistically significant change in consumption trend (ramps) in all evaluated indicators. No statistically significant changes in consumption levels and trends were observed in the control group. Conclusion: The ASP implemented in Dong Thap General Hospital from 2017 to 2021 showed a considerable influence on antibiotic consumption as indicated by the DOT/1000 PD and LOT/1000 PD during the initial stages. Moreover, controlling antibiotic consumption did not negatively impact patient outcomes.http://www.sciencedirect.com/science/article/pii/S2590088923000446Antimicrobial stewardship programInterrupted time-series analysisDefined daily doseDay of therapyLength of therapy |
| spellingShingle | Hai-Yen Nguyen-Thi Tran Viet Bui Hong-Nguyen Tran-Thi Anh Dang Minh Le Bao Dang Gia Nguyen Hong-Nhung Tran-Thi Thien Nguyen Nguyen Dang Tu Le Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021 Infection Prevention in Practice Antimicrobial stewardship program Interrupted time-series analysis Defined daily dose Day of therapy Length of therapy |
| title | Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021 |
| title_full | Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021 |
| title_fullStr | Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021 |
| title_full_unstemmed | Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021 |
| title_short | Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021 |
| title_sort | evaluation of the impact before and after the application of an antimicrobial stewardship program at dong thap general hospital vietnam from 2017 to 2021 |
| topic | Antimicrobial stewardship program Interrupted time-series analysis Defined daily dose Day of therapy Length of therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590088923000446 |
| work_keys_str_mv | AT haiyennguyenthi evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT tranvietbui evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT hongnguyentranthi evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT anhdangminhle evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT baodanggianguyen evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT hongnhungtranthi evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT thiennguyen evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 AT nguyendangtule evaluationoftheimpactbeforeandaftertheapplicationofanantimicrobialstewardshipprogramatdongthapgeneralhospitalvietnamfrom2017to2021 |