ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19352-1 |
| _version_ | 1830299825940201472 |
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| author | Ramesh B. Kasetti Pinkal D. Patel Prabhavathi Maddineni Shruti Patil Charles Kiehlbauch J. Cameron Millar Charles C. Searby VijayKrishna Raghunathan Val C. Sheffield Gulab S. Zode |
| author_facet | Ramesh B. Kasetti Pinkal D. Patel Prabhavathi Maddineni Shruti Patil Charles Kiehlbauch J. Cameron Millar Charles C. Searby VijayKrishna Raghunathan Val C. Sheffield Gulab S. Zode |
| author_sort | Ramesh B. Kasetti |
| collection | DOAJ |
| description | Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy. |
| first_indexed | 2024-12-19T08:15:57Z |
| format | Article |
| id | doaj.art-066b0588eecd45bc90ad78f0bc0e7443 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:15:57Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-066b0588eecd45bc90ad78f0bc0e74432022-12-21T20:29:30ZengNature PortfolioNature Communications2041-17232020-11-0111111410.1038/s41467-020-19352-1ATF4 leads to glaucoma by promoting protein synthesis and ER client protein loadRamesh B. Kasetti0Pinkal D. Patel1Prabhavathi Maddineni2Shruti Patil3Charles Kiehlbauch4J. Cameron Millar5Charles C. Searby6VijayKrishna Raghunathan7Val C. Sheffield8Gulab S. Zode9Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthDepartment of Pediatrics, Carver College of Medicine, University of IowaDepartment of Basic Sciences and the Ocular Surface Institute, College of Optometry, University of HoustonDepartment of Pediatrics, Carver College of Medicine, University of IowaDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort WorthGlaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.https://doi.org/10.1038/s41467-020-19352-1 |
| spellingShingle | Ramesh B. Kasetti Pinkal D. Patel Prabhavathi Maddineni Shruti Patil Charles Kiehlbauch J. Cameron Millar Charles C. Searby VijayKrishna Raghunathan Val C. Sheffield Gulab S. Zode ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load Nature Communications |
| title | ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load |
| title_full | ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load |
| title_fullStr | ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load |
| title_full_unstemmed | ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load |
| title_short | ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load |
| title_sort | atf4 leads to glaucoma by promoting protein synthesis and er client protein load |
| url | https://doi.org/10.1038/s41467-020-19352-1 |
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