Targeted disruption of the BCR-ABL fusion gene by Cas9/dual-sgRNA inhibits proliferation and induces apoptosis in chronic myeloid leukemia cells

Targeted disruption of the BCR-ABL fusion gene by Cas9/dual-sgRNA inhibits proliferation and induces apoptosis in chronic myeloid leukemia cells

The BCR-ABL fusion gene, formed by the fusion of the breakpoint cluster region protein (BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase (ABL) genes, encodes the BCR-ABL oncoprotein, which plays a crucial role in leukemogenesis. Current therapies have limited efficacy in patients with chronic m...

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Bibliographic Details
Main Authors: Zeng Jianling, Liang Xinquan, Duan Lili, Tan Fenghua, Chen Liujie, Qu Jiayao, Li Jia, Li Kai, Luo Dixian, Hu Zheng
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
CRISPR/Cas9
dual sgRNA
<italic>BCR-ABL</italic>
chronic myeloid leukemia (CML)
cell proliferation
apoptosis
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023280

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