In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT
Background: The effect of elevated progesterone level on human chorionic gonadotropin (HCG) day in in vitro fertilization cycles is controversial. Some suppose that rise in progesterone level seems to have a negative impact on implantation and pregnancy by desynchronizing the endometrium, while othe...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2017-12-01
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| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-356&slc_lang=en&sid=1 |
| _version_ | 1818279394895986688 |
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| author | Marzieh Aghahosseini Ashraf Aleyasin Fatemeh Sadat Sarfjoo Atossa Mahdavi Mansooreh Yaraghi Hojattollah Saeedabadi |
| author_facet | Marzieh Aghahosseini Ashraf Aleyasin Fatemeh Sadat Sarfjoo Atossa Mahdavi Mansooreh Yaraghi Hojattollah Saeedabadi |
| author_sort | Marzieh Aghahosseini |
| collection | DOAJ |
| description | Background: The effect of elevated progesterone level on human chorionic gonadotropin (HCG) day in in vitro fertilization cycles is controversial. Some suppose that rise in progesterone level seems to have a negative impact on implantation and pregnancy by desynchronizing the endometrium, while others disagree. Objective: To evaluate the superiority of the frozen cycle over fresh cycle on live birth in patients with elevated progesterone level on HCG day. Materials and Methods: In this double-blind, randomized clinical trial, 72 women undergoing assisted reproductive technology with elevated progesterone level (≥1.8 ng/dl) on HCG day were included. The participants were grouped by fresh versus frozen embryo transfer, randomly. Finally, the clinical pregnancy and live birth rate were compared. Results: The implantation rate was 21.51%. The clinical pregnancy rate was 47.22% in fresh embryo transfer group (17/36) and 41.66% in frozen group (15/36) (p=0. 40). The live birth rate was not significantly difference between two groups (p=0.56). Conclusion: None of the fresh and frozen cycles are superior to the other and we recommend individualizing the decision for each patient. The frozen cycle may impose more emotional stress on patients |
| first_indexed | 2024-12-12T23:32:38Z |
| format | Article |
| id | doaj.art-066fbf09b4e6480d9b382f6a4b5581da |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-12-12T23:32:38Z |
| publishDate | 2017-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-066fbf09b4e6480d9b382f6a4b5581da2022-12-22T00:07:39ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722017-12-011512757762In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCTMarzieh Aghahosseini0Ashraf Aleyasin1Fatemeh Sadat Sarfjoo2Atossa Mahdavi3Mansooreh Yaraghi4Hojattollah Saeedabadi5 Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Obstetrics and Gynecology and Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Obstetrics, Gynecology and Pelvic Floor Disorders, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Department of Embryology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Background: The effect of elevated progesterone level on human chorionic gonadotropin (HCG) day in in vitro fertilization cycles is controversial. Some suppose that rise in progesterone level seems to have a negative impact on implantation and pregnancy by desynchronizing the endometrium, while others disagree. Objective: To evaluate the superiority of the frozen cycle over fresh cycle on live birth in patients with elevated progesterone level on HCG day. Materials and Methods: In this double-blind, randomized clinical trial, 72 women undergoing assisted reproductive technology with elevated progesterone level (≥1.8 ng/dl) on HCG day were included. The participants were grouped by fresh versus frozen embryo transfer, randomly. Finally, the clinical pregnancy and live birth rate were compared. Results: The implantation rate was 21.51%. The clinical pregnancy rate was 47.22% in fresh embryo transfer group (17/36) and 41.66% in frozen group (15/36) (p=0. 40). The live birth rate was not significantly difference between two groups (p=0.56). Conclusion: None of the fresh and frozen cycles are superior to the other and we recommend individualizing the decision for each patient. The frozen cycle may impose more emotional stress on patientshttp://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-356&slc_lang=en&sid=1Progesterone Embryo transfer Pregnancy |
| spellingShingle | Marzieh Aghahosseini Ashraf Aleyasin Fatemeh Sadat Sarfjoo Atossa Mahdavi Mansooreh Yaraghi Hojattollah Saeedabadi In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT International Journal of Reproductive BioMedicine Progesterone Embryo transfer Pregnancy |
| title | In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT |
| title_full | In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT |
| title_fullStr | In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT |
| title_full_unstemmed | In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT |
| title_short | In vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of HCG injection: An RCT |
| title_sort | in vitro fertilization outcome in frozen versus fresh embryo transfer in women with elevated progesterone level on the day of hcg injection an rct |
| topic | Progesterone Embryo transfer Pregnancy |
| url | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-356&slc_lang=en&sid=1 |
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