Antistaphylococcal Activity of Selected Thiourea Derivatives
Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-12-01
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| Series: | Polish Journal of Microbiology |
| Subjects: | |
| Online Access: | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/65/4/pdf/10.5604_17331331.1227671.pdf |
| _version_ | 1818508004218109952 |
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| author | Joanna Stefańska Karolina Stępień Anna Bielenica Małgorzata Wrzosek Marta Struga |
| author_facet | Joanna Stefańska Karolina Stępień Anna Bielenica Małgorzata Wrzosek Marta Struga |
| author_sort | Joanna Stefańska |
| collection | DOAJ |
| description | Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Inhibitory activity of thioureas 2 and 3 against Staphylococcus aureus topoisomerase IV was studied. The examined compounds were nongenotoxic. |
| first_indexed | 2024-12-10T22:25:55Z |
| format | Article |
| id | doaj.art-0673b8a253a4452c8967e778163d7a44 |
| institution | Directory Open Access Journal |
| issn | 1733-1331 2544-4646 |
| language | English |
| last_indexed | 2024-12-10T22:25:55Z |
| publishDate | 2016-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Polish Journal of Microbiology |
| spelling | doaj.art-0673b8a253a4452c8967e778163d7a442022-12-22T01:31:10ZengSciendoPolish Journal of Microbiology1733-13312544-46462016-12-0165410.5604/17331331.1227671Antistaphylococcal Activity of Selected Thiourea DerivativesJoanna Stefańska0Karolina Stępień1Anna Bielenica2Małgorzata Wrzosek3Marta Struga4Department of Pharmaceutical Microbiology, Medical University of Warsaw, PolandDepartment of Pharmaceutical Microbiology, Medical University of Warsaw, PolandChair and Department of Biochemistry, Medical University of Warsaw, PolandDepartment of Pharmacogenomics, Faculty of Pharmacy, Medical University, Warsaw, PolandDepartment of Pharmacogenomics, Faculty of Pharmacy, Medical University, Warsaw, PolandFive of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol-2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Inhibitory activity of thioureas 2 and 3 against Staphylococcus aureus topoisomerase IV was studied. The examined compounds were nongenotoxic.https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/65/4/pdf/10.5604_17331331.1227671.pdfantistaphylococcal activityanti-biofilm activitygenotoxicitythiourea derivatives |
| spellingShingle | Joanna Stefańska Karolina Stępień Anna Bielenica Małgorzata Wrzosek Marta Struga Antistaphylococcal Activity of Selected Thiourea Derivatives Polish Journal of Microbiology antistaphylococcal activity anti-biofilm activity genotoxicity thiourea derivatives |
| title | Antistaphylococcal Activity of Selected Thiourea Derivatives |
| title_full | Antistaphylococcal Activity of Selected Thiourea Derivatives |
| title_fullStr | Antistaphylococcal Activity of Selected Thiourea Derivatives |
| title_full_unstemmed | Antistaphylococcal Activity of Selected Thiourea Derivatives |
| title_short | Antistaphylococcal Activity of Selected Thiourea Derivatives |
| title_sort | antistaphylococcal activity of selected thiourea derivatives |
| topic | antistaphylococcal activity anti-biofilm activity genotoxicity thiourea derivatives |
| url | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/65/4/pdf/10.5604_17331331.1227671.pdf |
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