Advanced Glycation End Products Impair Ca2+ Mobilization and Sensitization in Colonic Smooth Muscle Cells via the CAMP/PKA Pathway

Advanced Glycation End Products Impair Ca2+ Mobilization and Sensitization in Colonic Smooth Muscle Cells via the CAMP/PKA Pathway

Background/Aims: Excessive production of advanced glycation end products (AGEs) has been implicated in diabetes-related complications. This study aimed to investigate the mechanism by which AGEs potentially contribute to diabetes-associated colonic dysmotility. Methods: Control and streptozotocin (S...

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Bibliographic Details
Main Authors: Ting Yu, Yun Wang, Dong Qian, Xiaomeng Sun, Yurong Tang, Xiaoxue Shen, Lin Lin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Diabetes
Colonic dysmotility
AGEs
RAGE
CAMP/PKA pathway
Online Access:https://www.karger.com/Article/FullText/482005

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