Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients
From a total of 71 laboratory-confirmed cases, three presymptomatic patients and 10 patients with entirely asymptomatic infections were identified. In two of the three incubation period patients, the viral titer in the presymptomatic period was very high (Ct value < 20). The median number of days...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122030299X |
| _version_ | 1819064265337733120 |
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| author | Seong Eun Kim Hae Seong Jeong Yohan Yu Sung Un Shin Soosung Kim Tae Hoon Oh Uh Jin Kim Seung-Ji Kang Hee-Chang Jang Sook-In Jung Kyung-Hwa Park |
| author_facet | Seong Eun Kim Hae Seong Jeong Yohan Yu Sung Un Shin Soosung Kim Tae Hoon Oh Uh Jin Kim Seung-Ji Kang Hee-Chang Jang Sook-In Jung Kyung-Hwa Park |
| author_sort | Seong Eun Kim |
| collection | DOAJ |
| description | From a total of 71 laboratory-confirmed cases, three presymptomatic patients and 10 patients with entirely asymptomatic infections were identified. In two of the three incubation period patients, the viral titer in the presymptomatic period was very high (Ct value < 20). The median number of days to first negative RT-PCR in the asymptomatic carriers was 4.5 (range 2.5–9), and all asymptomatic carriers reached a first RT-PCR Ct > 35 within 14 days after diagnosis. Patients who have COVID-19 may already be infectious before there are symptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases. |
| first_indexed | 2024-12-21T15:27:49Z |
| format | Article |
| id | doaj.art-06763e75098e4cbc884321fb66ee7814 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-21T15:27:49Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-06763e75098e4cbc884321fb66ee78142022-12-21T18:58:51ZengElsevierInternational Journal of Infectious Diseases1201-97122020-06-0195441443Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patientsSeong Eun Kim0Hae Seong Jeong1Yohan Yu2Sung Un Shin3Soosung Kim4Tae Hoon Oh5Uh Jin Kim6Seung-Ji Kang7Hee-Chang Jang8Sook-In Jung9Kyung-Hwa Park10Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea; Chonnam National University Medical School, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea; Chonnam National University Medical School, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea; Chonnam National University Medical School, Gwangju, South KoreaDepartment of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea; Chonnam National University Medical School, Gwangju, South Korea; Corresponding author. Department of Infectious Diseases, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, South Korea. Tel: +82 62 220 6502, Fax: +82 62 225 8578.Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea; Chonnam National University Medical School, Gwangju, South Korea; Corresponding author. Department of Infectious Diseases, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, South Korea. Tel.: +82 62 220 6296, Fax: +82 62 225 8578.From a total of 71 laboratory-confirmed cases, three presymptomatic patients and 10 patients with entirely asymptomatic infections were identified. In two of the three incubation period patients, the viral titer in the presymptomatic period was very high (Ct value < 20). The median number of days to first negative RT-PCR in the asymptomatic carriers was 4.5 (range 2.5–9), and all asymptomatic carriers reached a first RT-PCR Ct > 35 within 14 days after diagnosis. Patients who have COVID-19 may already be infectious before there are symptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases.http://www.sciencedirect.com/science/article/pii/S120197122030299XCOVID-19Asymptomatic carrierPresymptomaticViral kineticsIsolation |
| spellingShingle | Seong Eun Kim Hae Seong Jeong Yohan Yu Sung Un Shin Soosung Kim Tae Hoon Oh Uh Jin Kim Seung-Ji Kang Hee-Chang Jang Sook-In Jung Kyung-Hwa Park Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients International Journal of Infectious Diseases COVID-19 Asymptomatic carrier Presymptomatic Viral kinetics Isolation |
| title | Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients |
| title_full | Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients |
| title_fullStr | Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients |
| title_full_unstemmed | Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients |
| title_short | Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients |
| title_sort | viral kinetics of sars cov 2 in asymptomatic carriers and presymptomatic patients |
| topic | COVID-19 Asymptomatic carrier Presymptomatic Viral kinetics Isolation |
| url | http://www.sciencedirect.com/science/article/pii/S120197122030299X |
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