Calcineurin inhibitors revisited: A new paradigm for COVID-19?
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than a direct viral damage disease. Therapies for COVI...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867020300842 |
| _version_ | 1828483523488514048 |
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| author | René Hage Carolin Steinack Macé M. Schuurmans |
| author_facet | René Hage Carolin Steinack Macé M. Schuurmans |
| author_sort | René Hage |
| collection | DOAJ |
| description | The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than a direct viral damage disease. Therapies for COVID-19 are all investigational therapies. In case of severe disease, treatment with a calcineurin inhibitor could be promising. In this article we explain the mechanisms of calcineurin inhibitor treatment for COVID-19, based on experiences seen in solid organ transplant recipients who suffered from COVID-19. |
| first_indexed | 2024-12-11T08:37:19Z |
| format | Article |
| id | doaj.art-06780325bbfa48c1b755f53bb88ed444 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-11T08:37:19Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-06780325bbfa48c1b755f53bb88ed4442022-12-22T01:14:19ZengElsevierBrazilian Journal of Infectious Diseases1413-86702020-07-01244365367Calcineurin inhibitors revisited: A new paradigm for COVID-19?René Hage0Carolin Steinack1Macé M. Schuurmans2University Hospital Zurich, Division of Pulmonology, Zurich, Switzerland; University of Zurich, Faculty of Medicine, Zurich, Switzerland; Corresponding author.University Hospital Zurich, Division of Pulmonology, Zurich, Switzerland; University of Zurich, Faculty of Medicine, Zurich, SwitzerlandUniversity Hospital Zurich, Division of Pulmonology, Zurich, Switzerland; University of Zurich, Faculty of Medicine, Zurich, SwitzerlandThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than a direct viral damage disease. Therapies for COVID-19 are all investigational therapies. In case of severe disease, treatment with a calcineurin inhibitor could be promising. In this article we explain the mechanisms of calcineurin inhibitor treatment for COVID-19, based on experiences seen in solid organ transplant recipients who suffered from COVID-19.http://www.sciencedirect.com/science/article/pii/S1413867020300842Cytokine stormHyperinflammationTransplantationARDS |
| spellingShingle | René Hage Carolin Steinack Macé M. Schuurmans Calcineurin inhibitors revisited: A new paradigm for COVID-19? Brazilian Journal of Infectious Diseases Cytokine storm Hyperinflammation Transplantation ARDS |
| title | Calcineurin inhibitors revisited: A new paradigm for COVID-19? |
| title_full | Calcineurin inhibitors revisited: A new paradigm for COVID-19? |
| title_fullStr | Calcineurin inhibitors revisited: A new paradigm for COVID-19? |
| title_full_unstemmed | Calcineurin inhibitors revisited: A new paradigm for COVID-19? |
| title_short | Calcineurin inhibitors revisited: A new paradigm for COVID-19? |
| title_sort | calcineurin inhibitors revisited a new paradigm for covid 19 |
| topic | Cytokine storm Hyperinflammation Transplantation ARDS |
| url | http://www.sciencedirect.com/science/article/pii/S1413867020300842 |
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