Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies

The prevalence of allergic diseases, such as asthma, rhinitis, eczema, and sick building syndrome (SBS), has increased drastically in the past few decades. Current medications can only relieve the symptoms but not cure these diseases whose development is suggested to be greatly impacted by the indoo...

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Main Authors: Xi Fu, Zheyuan Ou, Yu Sun
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Eco-Environment & Health
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S277298502200031X
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author Xi Fu
Zheyuan Ou
Yu Sun
author_facet Xi Fu
Zheyuan Ou
Yu Sun
author_sort Xi Fu
collection DOAJ
description The prevalence of allergic diseases, such as asthma, rhinitis, eczema, and sick building syndrome (SBS), has increased drastically in the past few decades. Current medications can only relieve the symptoms but not cure these diseases whose development is suggested to be greatly impacted by the indoor microbiome. However, no study comprehensively summarizes the progress and general rules in the field, impeding subsequent translational application. To close knowledge gaps between theoretical research and practical application, we conducted a comprehensive literature review to summarize the epidemiological, environmental, and molecular evidence of indoor microbiome studies. Epidemiological evidence shows that the potential protective indoor microorganisms for asthma are mainly from the phyla Actinobacteria and Proteobacteria, and the risk microorganisms are mainly from Bacilli, Clostridia, and Bacteroidia. Due to extremely high microbial diversity and geographic variation, different health-associated species/genera are detected in different regions. Compared with indoor microbial composition, indoor metabolites show more consistent associations with health, including microbial volatile organic compounds (MVOCs), lipopolysaccharides (LPS), indole derivatives, and flavonoids. Therefore, indoor metabolites could be a better indicator than indoor microbial taxa for environmental assessments and health outcome prediction. The interaction between the indoor microbiome and environmental characteristics (surrounding greenness, relative humidity, building confinement, and CO2 concentration) and immunology effects of indoor microorganisms (inflammatory cytokines and pattern recognition receptors) are briefly reviewed to provide new insights for disease prevention and treatment. Widely used tools in indoor microbiome studies are introduced to facilitate standard practice and the precise identification of health-related targets.
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spelling doaj.art-0679abf54c1b419792ba8d325b42d0c22024-01-25T05:24:27ZengElsevierEco-Environment & Health2772-98502022-09-0113133146Indoor microbiome and allergic diseases: From theoretical advances to prevention strategiesXi Fu0Zheyuan Ou1Yu Sun2School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, ChinaGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; Corresponding author.The prevalence of allergic diseases, such as asthma, rhinitis, eczema, and sick building syndrome (SBS), has increased drastically in the past few decades. Current medications can only relieve the symptoms but not cure these diseases whose development is suggested to be greatly impacted by the indoor microbiome. However, no study comprehensively summarizes the progress and general rules in the field, impeding subsequent translational application. To close knowledge gaps between theoretical research and practical application, we conducted a comprehensive literature review to summarize the epidemiological, environmental, and molecular evidence of indoor microbiome studies. Epidemiological evidence shows that the potential protective indoor microorganisms for asthma are mainly from the phyla Actinobacteria and Proteobacteria, and the risk microorganisms are mainly from Bacilli, Clostridia, and Bacteroidia. Due to extremely high microbial diversity and geographic variation, different health-associated species/genera are detected in different regions. Compared with indoor microbial composition, indoor metabolites show more consistent associations with health, including microbial volatile organic compounds (MVOCs), lipopolysaccharides (LPS), indole derivatives, and flavonoids. Therefore, indoor metabolites could be a better indicator than indoor microbial taxa for environmental assessments and health outcome prediction. The interaction between the indoor microbiome and environmental characteristics (surrounding greenness, relative humidity, building confinement, and CO2 concentration) and immunology effects of indoor microorganisms (inflammatory cytokines and pattern recognition receptors) are briefly reviewed to provide new insights for disease prevention and treatment. Widely used tools in indoor microbiome studies are introduced to facilitate standard practice and the precise identification of health-related targets.http://www.sciencedirect.com/science/article/pii/S277298502200031XIndoor microbial metaboliteAsthmaRhinitisEczemaSick building syndromeEnvironmental characteristic
spellingShingle Xi Fu
Zheyuan Ou
Yu Sun
Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
Eco-Environment & Health
Indoor microbial metabolite
Asthma
Rhinitis
Eczema
Sick building syndrome
Environmental characteristic
title Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
title_full Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
title_fullStr Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
title_full_unstemmed Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
title_short Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
title_sort indoor microbiome and allergic diseases from theoretical advances to prevention strategies
topic Indoor microbial metabolite
Asthma
Rhinitis
Eczema
Sick building syndrome
Environmental characteristic
url http://www.sciencedirect.com/science/article/pii/S277298502200031X
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AT zheyuanou indoormicrobiomeandallergicdiseasesfromtheoreticaladvancestopreventionstrategies
AT yusun indoormicrobiomeandallergicdiseasesfromtheoreticaladvancestopreventionstrategies