Experimental evolution of an RNA virus in wild birds: evidence for host-dependent impacts on population structure and competitive fitness.

Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and selective mechanisms that are incompletely understood. Defining how natural selection shapes RNA virus...

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Bibliographic Details
Main Authors: Nathan D Grubaugh, Darci R Smith, Doug E Brackney, Angela M Bosco-Lauth, Joseph R Fauver, Corey L Campbell, Todd A Felix, Hannah Romo, Nisha K Duggal, Elizabeth A Dietrich, Tyler Eike, Jennifer E Beane, Richard A Bowen, William C Black, Aaron C Brault, Gregory D Ebel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4439088?pdf=render

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