A Comparitive Study to Evaluate the Role of Serum Lipid Levels in Aetiology of Carcinoma Breast
Introduction: Breast cancer is the most common occurring cancer in women worldwide. Various factors that have lead to change in lifestyle are thought to be associated with increase in breast cancer incidence in Asian countries. Several clinical studies suggest the prognostic significance of seru...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5563/12273_CE[Ra]_F(P)_PF1(NJAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Breast cancer is the most common occurring
cancer in women worldwide. Various factors that have lead to
change in lifestyle are thought to be associated with increase
in breast cancer incidence in Asian countries. Several clinical
studies suggest the prognostic significance of serum lipid levels
in breast cancer. Present study was planned to confirm the
association of lipids levels with breast cancer.
Materials and Methods: Lipid analyses was carried out
on serum samples from 100 breast cancer patients and 100
control women, with a age group of 25 y and above. The case
& control group included 50 premenopausal women and 50
postmenopausal women.
Results: Patients of study group had high Low density
lipoproteins (LDL) (p-value - 0.00), Triglycerides (TG) (p-value
-0.001) and Total cholesterol (TC) (p-value -0.00) as compared
to control group. There was no association of VLDL (p-value
-0.436) and HDL (p-value -0.797) among study group and
control group. There was no association of lipid levels in different
grades of carcinoma.
Conclusion: High levels of LDL, TG and TC were associated with
breast cancer. However, no association was there in different
grades of carcinoma. So it may be concluded that, LDL, TG
and TC may be having some role in aetiology of breast cancer.
Therefore, early detection and control of these factors may help
in reducing the incidence of breast cancer and ultimately social
and economic burden on society. |
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| ISSN: | 2249-782X 0973-709X |