Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region
Characteristics of chronic milk-dependent food protein-induced enterocolitis syndrome (FPIES) in children from the region of Western Pomerania were studied. Prospectively, 55 children were diagnosed at a median of 2.2 months. The open food challenges (OFC), morphologies, milk-specific IgE (sIgE) (FE...
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MDPI AG
2021-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/4137 |
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| author | Karolina Bulsa Małgorzata Standowicz Elżbieta Baryła-Pankiewicz Grażyna Czaja-Bulsa |
| author_facet | Karolina Bulsa Małgorzata Standowicz Elżbieta Baryła-Pankiewicz Grażyna Czaja-Bulsa |
| author_sort | Karolina Bulsa |
| collection | DOAJ |
| description | Characteristics of chronic milk-dependent food protein-induced enterocolitis syndrome (FPIES) in children from the region of Western Pomerania were studied. Prospectively, 55 children were diagnosed at a median of 2.2 months. The open food challenges (OFC), morphologies, milk-specific IgE (sIgE) (FEIA method, CAP system), and skin prick tests (SPTs) were examined. Vomiting and diarrhea escalated gradually but quickly led to growth retardation. Of the infants, 49% had BMI < 10 c, 20% BMI < 3 c; 25% had anemia, and 15% had hypoalbuminemia. During the OFCs we observed acute symptoms that appeared after 2–3 h: vomiting diarrhea and pallor. A total of 42% children required intravenous hydration. Casein hydrolysates or amino acids formulae (20%) were used in treatment. In 25% of children, SPT and milk sIgE were found, in 18%—other food SPTs, and in 14% allergy to other foods. A transition to IgE-dependent milk allergy was seen in 3 children. In the twelfth month of life, 62% of children had tolerance to milk, and in the twenty-fifth month—87%. Conclusions. Chronic milk-dependent FPIES resolves in most children. By the age of 2 children are at risk of multiple food sensitization, and those who have milk sIgE are at risk to transition to IgE-mediated milk allergy. Every OFC needs to be supervised due to possible severe reactions. |
| first_indexed | 2024-03-10T05:10:32Z |
| format | Article |
| id | doaj.art-067e21d101b94b498b181addace3d8cd |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:10:32Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-067e21d101b94b498b181addace3d8cd2023-11-23T00:51:14ZengMDPI AGNutrients2072-66432021-11-011311413710.3390/nu13114137Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania RegionKarolina Bulsa0Małgorzata Standowicz1Elżbieta Baryła-Pankiewicz2Grażyna Czaja-Bulsa3Szczecin Outpatient Clinic, 71-050 Szczecin, PolandDoctoral Studies, Pomeranian Medical University, 70-204 Szczecin, PolandNeonatology Clinic, Pomeranian Medical University, 70-204 Police, PolandChair and Department of Paediatrics and Paediatric Nursing, Pomeranian Medical University, 70-204 Szczecin, PolandCharacteristics of chronic milk-dependent food protein-induced enterocolitis syndrome (FPIES) in children from the region of Western Pomerania were studied. Prospectively, 55 children were diagnosed at a median of 2.2 months. The open food challenges (OFC), morphologies, milk-specific IgE (sIgE) (FEIA method, CAP system), and skin prick tests (SPTs) were examined. Vomiting and diarrhea escalated gradually but quickly led to growth retardation. Of the infants, 49% had BMI < 10 c, 20% BMI < 3 c; 25% had anemia, and 15% had hypoalbuminemia. During the OFCs we observed acute symptoms that appeared after 2–3 h: vomiting diarrhea and pallor. A total of 42% children required intravenous hydration. Casein hydrolysates or amino acids formulae (20%) were used in treatment. In 25% of children, SPT and milk sIgE were found, in 18%—other food SPTs, and in 14% allergy to other foods. A transition to IgE-dependent milk allergy was seen in 3 children. In the twelfth month of life, 62% of children had tolerance to milk, and in the twenty-fifth month—87%. Conclusions. Chronic milk-dependent FPIES resolves in most children. By the age of 2 children are at risk of multiple food sensitization, and those who have milk sIgE are at risk to transition to IgE-mediated milk allergy. Every OFC needs to be supervised due to possible severe reactions.https://www.mdpi.com/2072-6643/13/11/4137milk allergychildrennon-IgE mediated CMAfood protein-induced enterocolitis syndromeFPIES |
| spellingShingle | Karolina Bulsa Małgorzata Standowicz Elżbieta Baryła-Pankiewicz Grażyna Czaja-Bulsa Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region Nutrients milk allergy children non-IgE mediated CMA food protein-induced enterocolitis syndrome FPIES |
| title | Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region |
| title_full | Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region |
| title_fullStr | Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region |
| title_full_unstemmed | Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region |
| title_short | Chronic Milk-Dependent Food Protein-Induced Enterocolitis Syndrome in Children from West Pomerania Region |
| title_sort | chronic milk dependent food protein induced enterocolitis syndrome in children from west pomerania region |
| topic | milk allergy children non-IgE mediated CMA food protein-induced enterocolitis syndrome FPIES |
| url | https://www.mdpi.com/2072-6643/13/11/4137 |
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