Consecutive intra-gingival injections of lipopolysaccharide and butyric acid to mice induce abnormal behavior and changes in cytokine concentrations

Consecutive intra-gingival injections of lipopolysaccharide and butyric acid to mice induce abnormal behavior and changes in cytokine concentrations

Abstract Background Periodontopathic bacteria such as Porphyromonas gingivalis produce several metabolites, including lipopolysaccharide (LPS) and n-butyric acid (BA). Past work suggested that periodontal infection may cause cognitive impairment in mice. Aims To elucidate the mechanisms by which met...

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Bibliographic Details
Main Authors: Takamitsu Tsukahara, Atsushi Toyoda, Takahiro Kawase, Shin-ichi Nakamura, Kuniyasu Ochiai
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Abnormal behavior
n-Butyric acid
Lipopolysaccharide
Mouse model
Porphyromonas gingivalis
Online Access:http://link.springer.com/article/10.1186/s12974-020-02008-8

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