Expert recommendations on blood purification treatment protocol for patients with severe COVID-19

Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international concern. Epidemiological data indicate that at least 20% of COVID-19 patients have severe di...

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Main Authors: Xiang-Hong Yang, Ren-Hua Sun, Ming-Yan Zhao, Er-Zhen Chen, Jiao Liu, Hong-Liang Wang, Rong-Li Yang, De-Chang Chen
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Chronic Diseases and Translational Medicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2095882X20300372
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author Xiang-Hong Yang
Ren-Hua Sun
Ming-Yan Zhao
Er-Zhen Chen
Jiao Liu
Hong-Liang Wang
Rong-Li Yang
De-Chang Chen
author_facet Xiang-Hong Yang
Ren-Hua Sun
Ming-Yan Zhao
Er-Zhen Chen
Jiao Liu
Hong-Liang Wang
Rong-Li Yang
De-Chang Chen
author_sort Xiang-Hong Yang
collection DOAJ
description Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international concern. Epidemiological data indicate that at least 20% of COVID-19 patients have severe disease. In addition to impairment of the respiratory system, acute kidney injury (AKI) is a major complication. Immune damage mediated by cytokine storms and concomitant AKI is a key factor for poor prognosis. Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. This protocol is divided into four major steps. The first step is to assess whether patients with severe COVID-19 require blood purification. The second step is to prescribe a blood purification treatment for patients with COVID-19. The third step is to monitor and adjust parameters of blood purification. The fourth step is to evaluate the timing of discontinuation of blood purification. It is expected that blood purification will play a key role in effectively reducing the mortality of patients with severe COVID-19 through the standardized implementation of the present protocol.
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spelling doaj.art-06810ccab53d49149b1c0067fe2b38032022-12-22T02:41:57ZengWileyChronic Diseases and Translational Medicine2095-882X2020-06-0162106114Expert recommendations on blood purification treatment protocol for patients with severe COVID-19Xiang-Hong Yang0Ren-Hua Sun1Ming-Yan Zhao2Er-Zhen Chen3Jiao Liu4Hong-Liang Wang5Rong-Li Yang6De-Chang Chen7Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, ChinaDepartment of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, ChinaDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Critical Care Medicine, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201800, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, ChinaDepartment of Critical Care Medicine, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, ChinaDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Corresponding author.Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international concern. Epidemiological data indicate that at least 20% of COVID-19 patients have severe disease. In addition to impairment of the respiratory system, acute kidney injury (AKI) is a major complication. Immune damage mediated by cytokine storms and concomitant AKI is a key factor for poor prognosis. Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. This protocol is divided into four major steps. The first step is to assess whether patients with severe COVID-19 require blood purification. The second step is to prescribe a blood purification treatment for patients with COVID-19. The third step is to monitor and adjust parameters of blood purification. The fourth step is to evaluate the timing of discontinuation of blood purification. It is expected that blood purification will play a key role in effectively reducing the mortality of patients with severe COVID-19 through the standardized implementation of the present protocol.http://www.sciencedirect.com/science/article/pii/S2095882X20300372COVID-19Blood purification treatmentSARS-CoV-2
spellingShingle Xiang-Hong Yang
Ren-Hua Sun
Ming-Yan Zhao
Er-Zhen Chen
Jiao Liu
Hong-Liang Wang
Rong-Li Yang
De-Chang Chen
Expert recommendations on blood purification treatment protocol for patients with severe COVID-19
Chronic Diseases and Translational Medicine
COVID-19
Blood purification treatment
SARS-CoV-2
title Expert recommendations on blood purification treatment protocol for patients with severe COVID-19
title_full Expert recommendations on blood purification treatment protocol for patients with severe COVID-19
title_fullStr Expert recommendations on blood purification treatment protocol for patients with severe COVID-19
title_full_unstemmed Expert recommendations on blood purification treatment protocol for patients with severe COVID-19
title_short Expert recommendations on blood purification treatment protocol for patients with severe COVID-19
title_sort expert recommendations on blood purification treatment protocol for patients with severe covid 19
topic COVID-19
Blood purification treatment
SARS-CoV-2
url http://www.sciencedirect.com/science/article/pii/S2095882X20300372
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