ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function

The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules. Previously, we have shown that genetic or pharmacological inhibition of ERAP1 on murine and human tumor cel...

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Bibliographic Details
Main Authors: Silvia D’Amico, Valerio D’Alicandro, Mirco Compagnone, Patrizia Tempora, Giusy Guida, Paolo Romania, Valeria Lucarini, Ombretta Melaiu, Michela Falco, Mattia Algeri, Daniela Pende, Loredana Cifaldi, Doriana Fruci
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
ERAP1
NK cells
NK cell immunotherapy
HLA class I
KIR
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.778103/full

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