Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia

Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia

Rett Syndrome (RTT) is a neurodevelopmental disorder caused by loss of function of the transcriptional regulator Methyl-CpG-Binding Protein 2 (MeCP2). In addition to the characteristic loss of hand function and spoken language after the first year of life, people with RTT also have a variety of phys...

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Bibliographic Details
Main Authors: Christopher S. Ward, Teng-Wei Huang, Jose A. Herrera, Rodney C. Samaco, Christopher M. McGraw, Diana E. Parra, E. Melissa Arvide, Aya Ito-Ishida, Xiangling Meng, Kerstin Ure, Huda Y. Zoghbi, Jeffrey L. Neul
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
Rett
MeCP2
hypoxia
sudden death
biomarker
breathing abnormalities
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.593554/full

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