Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs
Vaterite CaCO3 crystals are actively used as a biocompatible and degradable matrix for encapsulation of fragile biomacromolecules. However, the incorporation of small cationic drugs into the crystals remains awkward due to a poor binding of these drugs to the crystal surface and scarce retention ins...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Materials & Design |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127519304587 |
| _version_ | 1831664436585168896 |
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| author | Nadezhda G. Balabushevich Ekaterina A. Kovalenko Irina M. Le-Deygen Lyubov Y. Filatova Dmitry Volodkin Anna S. Vikulina |
| author_facet | Nadezhda G. Balabushevich Ekaterina A. Kovalenko Irina M. Le-Deygen Lyubov Y. Filatova Dmitry Volodkin Anna S. Vikulina |
| author_sort | Nadezhda G. Balabushevich |
| collection | DOAJ |
| description | Vaterite CaCO3 crystals are actively used as a biocompatible and degradable matrix for encapsulation of fragile biomacromolecules. However, the incorporation of small cationic drugs into the crystals remains awkward due to a poor binding of these drugs to the crystal surface and scarce retention inside the crystal pores. Herein, we achieve efficient drug loading and control over drug release performance via utilisation of hybrid CaCO3 crystals impregnated with mucin. The co-loading of mucin and anticancer drug doxorubicin (DOX) into CaCO3 crystals enhanced drug content in the crystals by ca 12 times giving DOX concentration of 1.3 mg g−1 CaCO3. Retention of DOX inside hybrid crystals is governed by strong electrostatic attraction to mucin matrix and significant narrowing of the crystal pores in the presence of mucin. At physiologically relevant conditions, DOX release kinetics strongly depends on the recrystallization of the porous vaterite to non-porous calcite that is regulated by mucin concentration. We believe that this study will help to design novel effective drug delivery systems able to load high amounts of drugs at mild conditions for sustained and controlled release of the drugs. This is indispensable for mucosal delivery where mucin produced by epithelial tissues is a main component. Keywords: Vaterite, Co-synthesis, Doxorubicin, Aprotinin, Prolonged release, Mucosal delivery |
| first_indexed | 2024-12-19T19:15:17Z |
| format | Article |
| id | doaj.art-0687ae4e6d0245aa87d0d5f80b4213bf |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-19T19:15:17Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-0687ae4e6d0245aa87d0d5f80b4213bf2022-12-21T20:09:08ZengElsevierMaterials & Design0264-12752019-11-01182Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugsNadezhda G. Balabushevich0Ekaterina A. Kovalenko1Irina M. Le-Deygen2Lyubov Y. Filatova3Dmitry Volodkin4Anna S. Vikulina5Lomonosov Moscow State University, Department of Chemistry, Leninskiye Gory 1-3, 119991 Moscow, RussiaLomonosov Moscow State University, Department of Chemistry, Leninskiye Gory 1-3, 119991 Moscow, RussiaLomonosov Moscow State University, Department of Chemistry, Leninskiye Gory 1-3, 119991 Moscow, RussiaLomonosov Moscow State University, Department of Chemistry, Leninskiye Gory 1-3, 119991 Moscow, RussiaLomonosov Moscow State University, Department of Chemistry, Leninskiye Gory 1-3, 119991 Moscow, Russia; Nottingham Trent University, School of Science and Technology, Clifton Lane, NG11 8NS Nottingham, UKNottingham Trent University, School of Science and Technology, Clifton Lane, NG11 8NS Nottingham, UK; Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses, Am Mühlenberg 13, 14476 Potsdam-Golm, Germany; Corresponding author at: Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses, Am Mühlenberg 13, 14476 Potsdam-Golm, Germany.Vaterite CaCO3 crystals are actively used as a biocompatible and degradable matrix for encapsulation of fragile biomacromolecules. However, the incorporation of small cationic drugs into the crystals remains awkward due to a poor binding of these drugs to the crystal surface and scarce retention inside the crystal pores. Herein, we achieve efficient drug loading and control over drug release performance via utilisation of hybrid CaCO3 crystals impregnated with mucin. The co-loading of mucin and anticancer drug doxorubicin (DOX) into CaCO3 crystals enhanced drug content in the crystals by ca 12 times giving DOX concentration of 1.3 mg g−1 CaCO3. Retention of DOX inside hybrid crystals is governed by strong electrostatic attraction to mucin matrix and significant narrowing of the crystal pores in the presence of mucin. At physiologically relevant conditions, DOX release kinetics strongly depends on the recrystallization of the porous vaterite to non-porous calcite that is regulated by mucin concentration. We believe that this study will help to design novel effective drug delivery systems able to load high amounts of drugs at mild conditions for sustained and controlled release of the drugs. This is indispensable for mucosal delivery where mucin produced by epithelial tissues is a main component. Keywords: Vaterite, Co-synthesis, Doxorubicin, Aprotinin, Prolonged release, Mucosal deliveryhttp://www.sciencedirect.com/science/article/pii/S0264127519304587 |
| spellingShingle | Nadezhda G. Balabushevich Ekaterina A. Kovalenko Irina M. Le-Deygen Lyubov Y. Filatova Dmitry Volodkin Anna S. Vikulina Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs Materials & Design |
| title | Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs |
| title_full | Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs |
| title_fullStr | Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs |
| title_full_unstemmed | Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs |
| title_short | Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs |
| title_sort | hybrid caco3 mucin crystals effective approach for loading and controlled release of cationic drugs |
| url | http://www.sciencedirect.com/science/article/pii/S0264127519304587 |
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