Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report)
Severe traumatic brain injury (TBI) accompanied by impaired consciousness manifesting as prolonged postcoma unawareness (PCU) is one of the current medical and social problems causing high morbidity and mortality worldwide. Difficult recovery of such patients necessitates the development of addition...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2022-04-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/2213 |
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| author | A. S. Zigmantovich E. V. Sharova M. М. Kopachka A. S. Smirnov E. V. Alexandrova Yu. V. Kotovich Ya. I. Deza-Araujo M. V. Stern E. M. Troshina I. N. Pronin |
| author_facet | A. S. Zigmantovich E. V. Sharova M. М. Kopachka A. S. Smirnov E. V. Alexandrova Yu. V. Kotovich Ya. I. Deza-Araujo M. V. Stern E. M. Troshina I. N. Pronin |
| author_sort | A. S. Zigmantovich |
| collection | DOAJ |
| description | Severe traumatic brain injury (TBI) accompanied by impaired consciousness manifesting as prolonged postcoma unawareness (PCU) is one of the current medical and social problems causing high morbidity and mortality worldwide. Difficult recovery of such patients necessitates the development of additional neurorehabilitation approaches, including neuromodulation methods, as well as the search for objective markers of treatment efficacy. Aim of the study: to evaluate the effect of therapeutic rhythmic transcranial magnetic stimulation (rTMS) on fMRI resting state networks (RSN) in PCU after severe TBI. Materials and Methods. We analyzed individual fMRI RSN in three patients with PCU before and after a course of rTMS performed at different timepoints after severe TBI and with different efficacy of treatment. We assessed the topography and quantitative characteristics of the networks (DMN, sensorimotor, control functions, left and right fronto-parietal, auditory, and speech) known to be most significant for recovery of consciousness. Results. We found a trend toward normalization of RSN topography as well as an increase in the integral index of network intensity in two of three patients with a distinct increase in consciousness after a course of rTMS. Conclusion. Using case observations, we have demonstrated the therapeutic efficacy of rTMS and feasibility of using fMRI RSN as a reliable diagnostic approach in PCU following severe TBI. |
| first_indexed | 2024-04-10T01:26:45Z |
| format | Article |
| id | doaj.art-06884c5d7b864b18a9c752d95d8dce9f |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:26:45Z |
| publishDate | 2022-04-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-06884c5d7b864b18a9c752d95d8dce9f2023-03-13T09:32:57ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102022-04-01182536410.15360/1813-9779-2022-2-53-641843Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report)A. S. Zigmantovich0E. V. Sharova1M. М. Kopachka2A. S. Smirnov3E. V. Alexandrova4Yu. V. Kotovich5Ya. I. Deza-Araujo6M. V. Stern7E. M. Troshina8I. N. Pronin9Институт высшей нервной деятельности и нейрофизиологии РАНИнститут высшей нервной деятельности и нейрофизиологии РАННациональный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко Минздрава РоссииНациональный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко Минздрава РоссииНациональный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко Минздрава РоссииНациональный исследовательский ядерный университет «Московский инженерно-физический институт»Женевский университетИнститут высшей нервной деятельности и нейрофизиологии РАН; Федеральный научно-клинический центр реаниматологии и реабилитологии (ФНКЦ РР)Национальный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко Минздрава РоссииНациональный медицинский исследовательский центр нейрохирургии им. акад. Н. Н. Бурденко Минздрава РоссииSevere traumatic brain injury (TBI) accompanied by impaired consciousness manifesting as prolonged postcoma unawareness (PCU) is one of the current medical and social problems causing high morbidity and mortality worldwide. Difficult recovery of such patients necessitates the development of additional neurorehabilitation approaches, including neuromodulation methods, as well as the search for objective markers of treatment efficacy. Aim of the study: to evaluate the effect of therapeutic rhythmic transcranial magnetic stimulation (rTMS) on fMRI resting state networks (RSN) in PCU after severe TBI. Materials and Methods. We analyzed individual fMRI RSN in three patients with PCU before and after a course of rTMS performed at different timepoints after severe TBI and with different efficacy of treatment. We assessed the topography and quantitative characteristics of the networks (DMN, sensorimotor, control functions, left and right fronto-parietal, auditory, and speech) known to be most significant for recovery of consciousness. Results. We found a trend toward normalization of RSN topography as well as an increase in the integral index of network intensity in two of three patients with a distinct increase in consciousness after a course of rTMS. Conclusion. Using case observations, we have demonstrated the therapeutic efficacy of rTMS and feasibility of using fMRI RSN as a reliable diagnostic approach in PCU following severe TBI.https://www.reanimatology.com/rmt/article/view/2213черепно-мозговая травмабессознательные состояниянейронные сети покояфмртртмс |
| spellingShingle | A. S. Zigmantovich E. V. Sharova M. М. Kopachka A. S. Smirnov E. V. Alexandrova Yu. V. Kotovich Ya. I. Deza-Araujo M. V. Stern E. M. Troshina I. N. Pronin Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report) Общая реаниматология черепно-мозговая травма бессознательные состояния нейронные сети покоя фмрт ртмс |
| title | Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report) |
| title_full | Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report) |
| title_fullStr | Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report) |
| title_full_unstemmed | Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report) |
| title_short | Changes in Resting fMRI Networks in Patients with Severe Traumatic Brain Injury During Therapeutic Rhythmic Transcranial Magnetic Stimulation (Case Report) |
| title_sort | changes in resting fmri networks in patients with severe traumatic brain injury during therapeutic rhythmic transcranial magnetic stimulation case report |
| topic | черепно-мозговая травма бессознательные состояния нейронные сети покоя фмрт ртмс |
| url | https://www.reanimatology.com/rmt/article/view/2213 |
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