Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection
Shortness of breath, chest pain, and palpitations occur as postacute sequelae of COVID-19, but whether symptoms are associated with echocardiographic abnormalities, cardiac biomarkers, or markers of systemic inflammation remains unknown. In a cross-sectional analysis, we assessed symptoms, performed...
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| Format: | Article |
| Language: | English |
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American Society for Clinical investigation
2022-05-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.157053 |
| _version_ | 1811237525157576704 |
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| author | Matthew S. Durstenfeld Michael J. Peluso J. Daniel Kelly Sithu Win Shreya Swaminathan Danny Li Victor M. Arechiga Victor Zepeda Kaiwen Sun Shirley Shao Christopher Hill Mireya I. Arreguin Scott Lu Rebecca Hoh Viva Tai Ahmed Chenna Brandon C. Yee John W. Winslow Christos J. Petropoulos John Kornak Timothy J. Henrich Jeffrey N. Martin Steven G. Deeks Priscilla Y. Hsue |
| author_facet | Matthew S. Durstenfeld Michael J. Peluso J. Daniel Kelly Sithu Win Shreya Swaminathan Danny Li Victor M. Arechiga Victor Zepeda Kaiwen Sun Shirley Shao Christopher Hill Mireya I. Arreguin Scott Lu Rebecca Hoh Viva Tai Ahmed Chenna Brandon C. Yee John W. Winslow Christos J. Petropoulos John Kornak Timothy J. Henrich Jeffrey N. Martin Steven G. Deeks Priscilla Y. Hsue |
| author_sort | Matthew S. Durstenfeld |
| collection | DOAJ |
| description | Shortness of breath, chest pain, and palpitations occur as postacute sequelae of COVID-19, but whether symptoms are associated with echocardiographic abnormalities, cardiac biomarkers, or markers of systemic inflammation remains unknown. In a cross-sectional analysis, we assessed symptoms, performed echocardiograms, and measured biomarkers among adults more than 8 weeks after confirmed SARS-CoV-2 infection. We modeled associations between symptoms and baseline characteristics, echocardiographic findings, and biomarkers using logistic regression. We enrolled 102 participants at a median of 7.2 months following COVID-19 onset; 47 individuals reported dyspnea, chest pain, or palpitations. Median age was 52 years, and 41% of participants were women. Female sex, hospitalization, IgG antibody against SARS-CoV-2 receptor binding domain, and C-reactive protein were associated with symptoms. Regarding echocardiographic findings, 4 of 47 participants (9%) with symptoms had pericardial effusions compared with 0 of 55 participants without symptoms; those with effusions had a median of 4 symptoms compared with a median of 1 symptom in those without effusions. There was no strong evidence for a relationship between symptoms and echocardiographic functional parameters or other biomarkers. Among adults more than 8 weeks after SARS-CoV-2 infection, SARS-CoV-2 RBD antibodies, markers of inflammation, and, possibly, pericardial effusions are associated with cardiopulmonary symptoms. Investigation into inflammation as a mechanism underlying postacute sequelae of COVID-19 is warranted. |
| first_indexed | 2024-04-12T12:25:03Z |
| format | Article |
| id | doaj.art-0689580da9d94c34af6d36c1994574ff |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-04-12T12:25:03Z |
| publishDate | 2022-05-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-0689580da9d94c34af6d36c1994574ff2022-12-22T03:33:10ZengAmerican Society for Clinical investigationJCI Insight2379-37082022-05-01710Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infectionMatthew S. DurstenfeldMichael J. PelusoJ. Daniel KellySithu WinShreya SwaminathanDanny LiVictor M. ArechigaVictor ZepedaKaiwen SunShirley ShaoChristopher HillMireya I. ArreguinScott LuRebecca HohViva TaiAhmed ChennaBrandon C. YeeJohn W. WinslowChristos J. PetropoulosJohn KornakTimothy J. HenrichJeffrey N. MartinSteven G. DeeksPriscilla Y. HsueShortness of breath, chest pain, and palpitations occur as postacute sequelae of COVID-19, but whether symptoms are associated with echocardiographic abnormalities, cardiac biomarkers, or markers of systemic inflammation remains unknown. In a cross-sectional analysis, we assessed symptoms, performed echocardiograms, and measured biomarkers among adults more than 8 weeks after confirmed SARS-CoV-2 infection. We modeled associations between symptoms and baseline characteristics, echocardiographic findings, and biomarkers using logistic regression. We enrolled 102 participants at a median of 7.2 months following COVID-19 onset; 47 individuals reported dyspnea, chest pain, or palpitations. Median age was 52 years, and 41% of participants were women. Female sex, hospitalization, IgG antibody against SARS-CoV-2 receptor binding domain, and C-reactive protein were associated with symptoms. Regarding echocardiographic findings, 4 of 47 participants (9%) with symptoms had pericardial effusions compared with 0 of 55 participants without symptoms; those with effusions had a median of 4 symptoms compared with a median of 1 symptom in those without effusions. There was no strong evidence for a relationship between symptoms and echocardiographic functional parameters or other biomarkers. Among adults more than 8 weeks after SARS-CoV-2 infection, SARS-CoV-2 RBD antibodies, markers of inflammation, and, possibly, pericardial effusions are associated with cardiopulmonary symptoms. Investigation into inflammation as a mechanism underlying postacute sequelae of COVID-19 is warranted.https://doi.org/10.1172/jci.insight.157053COVID-19Cardiology |
| spellingShingle | Matthew S. Durstenfeld Michael J. Peluso J. Daniel Kelly Sithu Win Shreya Swaminathan Danny Li Victor M. Arechiga Victor Zepeda Kaiwen Sun Shirley Shao Christopher Hill Mireya I. Arreguin Scott Lu Rebecca Hoh Viva Tai Ahmed Chenna Brandon C. Yee John W. Winslow Christos J. Petropoulos John Kornak Timothy J. Henrich Jeffrey N. Martin Steven G. Deeks Priscilla Y. Hsue Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection JCI Insight COVID-19 Cardiology |
| title | Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection |
| title_full | Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection |
| title_fullStr | Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection |
| title_full_unstemmed | Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection |
| title_short | Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection |
| title_sort | role of antibodies inflammatory markers and echocardiographic findings in postacute cardiopulmonary symptoms after sars cov 2 infection |
| topic | COVID-19 Cardiology |
| url | https://doi.org/10.1172/jci.insight.157053 |
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