Verification of prognostic expression biomarkers is improved by examining enriched leukemic blasts rather than mononuclear cells from acute myeloid leukemia patients

Verification of prognostic expression biomarkers is improved by examining enriched leukemic blasts rather than mononuclear cells from acute myeloid leukemia patients

Abstract Background Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myeloid leukemia. We hypothesized that examining the homogenous leukemic bl...

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Bibliographic Details
Main Authors: Era L. Pogosova-Agadjanyan, Xing Hua, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, Harry P. Erba, Matthew P. Fitzgibbon, Isaac C. Jenkins, Min Fang, Stanley C. Lee, Anna Moseley, Jasmine Naru, Jerald P. Radich, Jenny L. Smith, Brooke E. Willborg, Cheryl L. Willman, Feinan Wu, Soheil Meshinchi, Derek L. Stirewalt
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biomarker Research
Subjects:
Biomarkers
Prognostic biomarkers
Genetic biomarkers
Hematological cancers
Leukemias
Acute myeloid leukemia
Online Access:https://doi.org/10.1186/s40364-023-00461-0

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