RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity

RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity

Despite substantial advances that have been made in understanding the etiology of hepatocellular carcinoma (HCC), the early-stage diagnosis and treatment of advanced-stage HCC remain a major challenge. RNF8, an E3 ligase important for the DNA damage response, has been proven to facilitate the progre...

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Bibliographic Details
Main Authors: Kuang Jingyu, Duan Ting, Gao Changsong, Liu Chuanyang, Chen Si, Zhu Lv-yun, Min Lu, Lu Chenyu, Wang Wenlun, Zhu Lingyun
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
hepatocellular carcinoma
epithelial-mesenchymal transition
RNF8
drug resistance
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023076

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