Neuroinflammation is not a prerequisite for diabetes-induced tau phosphorylation

Neuroinflammation is not a prerequisite for diabetes-induced tau phosphorylation

Abnormal phosphorylation and aggregation of tau is a key hallmark of Alzheimer's disease (AD). AD is a multifactorial neurodegenerative disorder for which Diabetes Mellitus (DM) is a risk factor. In animal models for DM, the phosphorylation and aggregation of tau is induced or exacerbated, howe...

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Bibliographic Details
Main Authors: Judith M Van Der Harg, Leslie eEggels, Silvie R Ruigrok, Jeroen JM Hoozemans, Susanne E la Fleur, Wiep eScheper
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Neuroscience
Subjects:
Diabetes Mellitus
Hippocampus
Inflammation
Alzheimer's disease
Cortex
diet-induced obesity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00432/full

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