Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus
Introduction: The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, wh...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8257/20156_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: The monitoring of glycaemic status in patients
with T2DM is mainly through blood tests (Fasting plasma glucose
and HbA1c), which are invasive and involves painful pricks.
This leads to poor patient compliance and soon could lead to
various micro and macro vascular complications, which hamper
the quality of life. There are no sensitive and specific markers
to predict these complications at the earliest. Sialochemistry
has recently gained attention for monitoring chronic diseases.
Osteopontin is a phospho-glycoprotein molecule, elevated in
many inflammatory conditions.
Aim: The aim of the study was to evaluate the role of serum and
salivary osteopontin in Type 2 Diabetes mellitus (T2DM).
Materials and Methods: In this case-control study, we recruited
33 cases of T2DM and 31 age and gender matched healthy
controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR),
Waist Circumference (WC) and blood pressure was recorded.
Fasting Plasma Glucose (FPG), salivary glucose, HbA1c,
microalbuminuria, systolic BP, serum and salivary osteopontin
levels were estimated.
Results: FPG, salivary glucose, HbA1c, microalbuminuria,
systolic BP, BMI, waist / hip ratio serum and salivary osteopontin
levels were significantly high in T2DM cases compared to
control subjects. Serum and salivary osteopontin levels were
significantly correlated with HbA1c and microalbuminuria in
T2DM cases.
Conclusion: Serum and salivary osteopontin levels are
significantly elevated in subjects with T2DM and are associated
with glycaemic control and microalbuminuria. |
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| ISSN: | 2249-782X 0973-709X |