Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus
Introduction: The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, wh...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8257/20156_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818682851858579456 |
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| author | Niranjan Gopal Reeta Rajagambeeram Shruthi Venkatkumar Mohana Valli Vijayan Sathish Babu Murugaiyan Shyam Prakash Gopal Sathiya Ramsamy Velayutharaj Alwar |
| author_facet | Niranjan Gopal Reeta Rajagambeeram Shruthi Venkatkumar Mohana Valli Vijayan Sathish Babu Murugaiyan Shyam Prakash Gopal Sathiya Ramsamy Velayutharaj Alwar |
| author_sort | Niranjan Gopal |
| collection | DOAJ |
| description | Introduction: The monitoring of glycaemic status in patients
with T2DM is mainly through blood tests (Fasting plasma glucose
and HbA1c), which are invasive and involves painful pricks.
This leads to poor patient compliance and soon could lead to
various micro and macro vascular complications, which hamper
the quality of life. There are no sensitive and specific markers
to predict these complications at the earliest. Sialochemistry
has recently gained attention for monitoring chronic diseases.
Osteopontin is a phospho-glycoprotein molecule, elevated in
many inflammatory conditions.
Aim: The aim of the study was to evaluate the role of serum and
salivary osteopontin in Type 2 Diabetes mellitus (T2DM).
Materials and Methods: In this case-control study, we recruited
33 cases of T2DM and 31 age and gender matched healthy
controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR),
Waist Circumference (WC) and blood pressure was recorded.
Fasting Plasma Glucose (FPG), salivary glucose, HbA1c,
microalbuminuria, systolic BP, serum and salivary osteopontin
levels were estimated.
Results: FPG, salivary glucose, HbA1c, microalbuminuria,
systolic BP, BMI, waist / hip ratio serum and salivary osteopontin
levels were significantly high in T2DM cases compared to
control subjects. Serum and salivary osteopontin levels were
significantly correlated with HbA1c and microalbuminuria in
T2DM cases.
Conclusion: Serum and salivary osteopontin levels are
significantly elevated in subjects with T2DM and are associated
with glycaemic control and microalbuminuria. |
| first_indexed | 2024-12-17T10:25:25Z |
| format | Article |
| id | doaj.art-068fcf560b52405b950624976440cd01 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-17T10:25:25Z |
| publishDate | 2016-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-068fcf560b52405b950624976440cd012022-12-21T21:52:40ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-08-01108BC06BC0810.7860/JCDR/2016/20156.8257Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes MellitusNiranjan Gopal0Reeta Rajagambeeram1Shruthi Venkatkumar2Mohana Valli Vijayan3Sathish Babu Murugaiyan4Shyam Prakash Gopal5Sathiya Ramsamy6Velayutharaj Alwar7Associate Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.Student, Indira Gandhi Institute of Dental Sciences (IGIDS), SBV (NAAC ‘A’ Grade), Pillaiyarkuppam, Pondicherry, India.Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.Student, M Pharm in Pharmacology, Mother Theresa Post Graduate and Research Institute of Health sciences, Indira Nagar, Gorimedu, Puducherry, India.Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Pondicherry, India.Assistant Professor, Department of Biochemistry, Chennai Medical College, Hospital & Research Centre, Trichy- Tamil Nadu, India.Introduction: The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, which hamper the quality of life. There are no sensitive and specific markers to predict these complications at the earliest. Sialochemistry has recently gained attention for monitoring chronic diseases. Osteopontin is a phospho-glycoprotein molecule, elevated in many inflammatory conditions. Aim: The aim of the study was to evaluate the role of serum and salivary osteopontin in Type 2 Diabetes mellitus (T2DM). Materials and Methods: In this case-control study, we recruited 33 cases of T2DM and 31 age and gender matched healthy controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR), Waist Circumference (WC) and blood pressure was recorded. Fasting Plasma Glucose (FPG), salivary glucose, HbA1c, microalbuminuria, systolic BP, serum and salivary osteopontin levels were estimated. Results: FPG, salivary glucose, HbA1c, microalbuminuria, systolic BP, BMI, waist / hip ratio serum and salivary osteopontin levels were significantly high in T2DM cases compared to control subjects. Serum and salivary osteopontin levels were significantly correlated with HbA1c and microalbuminuria in T2DM cases. Conclusion: Serum and salivary osteopontin levels are significantly elevated in subjects with T2DM and are associated with glycaemic control and microalbuminuria.https://jcdr.net/articles/PDF/8257/20156_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdfdiabetic nephropathyfasting plasma glucosehba1c |
| spellingShingle | Niranjan Gopal Reeta Rajagambeeram Shruthi Venkatkumar Mohana Valli Vijayan Sathish Babu Murugaiyan Shyam Prakash Gopal Sathiya Ramsamy Velayutharaj Alwar Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus Journal of Clinical and Diagnostic Research diabetic nephropathy fasting plasma glucose hba1c |
| title | Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus |
| title_full | Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus |
| title_short | Association of Salivary Osteopontin Levels with Glycaemic Status and Microalbuminuria - in Patients with Type 2 Diabetes Mellitus |
| title_sort | association of salivary osteopontin levels with glycaemic status and microalbuminuria in patients with type 2 diabetes mellitus |
| topic | diabetic nephropathy fasting plasma glucose hba1c |
| url | https://jcdr.net/articles/PDF/8257/20156_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
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