Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults
In many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection al...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Parasite Epidemiology and Control |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240567311630037X |
| _version_ | 1818129498894237696 |
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| author | Helen L. Storey Benson Singa Jackie Naulikha Helen Horton Barbra A. Richardson Grace John-Stewart Judd L. Walson |
| author_facet | Helen L. Storey Benson Singa Jackie Naulikha Helen Horton Barbra A. Richardson Grace John-Stewart Judd L. Walson |
| author_sort | Helen L. Storey |
| collection | DOAJ |
| description | In many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection alters unstimulated vaccine responses among HIV-1 infected individuals, we conducted two nested serologic studies. Blood samples were collected for HIV disease monitoring and vaccine-specific serologic assays, while stool was evaluated by direct microscopy methods. We compared antibody responses to measles and tetanus vaccines in helminth-infected (Ascaris, Trichuris, hookworm and/or Schistosoma mansoni) and uninfected adults 18 years and older (n = 100). We also compared measles and tetanus antibody responses in Ascaris only-infected adults receiving 400 mg albendazole daily for 3 days (n = 16) vs. placebo (n = 19) in a separate study. In both cohorts, over 70% of participants had measles and tetanus responses above the protective threshold. Prevalence of measles responses were similar between helminth-infected and uninfected individuals (82%, 95% CI: 71–93% vs 72%, 95% CI: 59–85%), as well as log10 tetanus antibody levels (−0.133 IU/mL vs −0.190 IU/mL, p > 0.05), and did not differ by helminth species. In the Ascaris-infected cohort, changes in measles responses and tetanus responses did not differ between those who received anthelminthic vs. placebo (p > 0.05 for both). In these studies, neither helminth infection, nor deworming, appeared to affect previously administered vaccine responsiveness in HIV-1 infected, ART naïve, adults in Kenya. |
| first_indexed | 2024-12-11T07:50:06Z |
| format | Article |
| id | doaj.art-068ff98543af4939be93fffa089f0e5a |
| institution | Directory Open Access Journal |
| issn | 2405-6731 |
| language | English |
| last_indexed | 2024-12-11T07:50:06Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Parasite Epidemiology and Control |
| spelling | doaj.art-068ff98543af4939be93fffa089f0e5a2022-12-22T01:15:21ZengElsevierParasite Epidemiology and Control2405-67312017-02-0121132010.1016/j.parepi.2016.12.003Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adultsHelen L. Storey0Benson Singa1Jackie Naulikha2Helen Horton3Barbra A. Richardson4Grace John-Stewart5Judd L. Walson6Department of Epidemiology, University of Washington, 325 9th Ave, Seattle, WA 98104, USAKenya Medical Research Institute, Mbagathi Rd, Nairobi, KenyaKenya Medical Research Institute, Mbagathi Rd, Nairobi, KenyaSeattle Biomedical Research Institute, 307 Westlake Ave N #500, Seattle, WA, USADepartment of Biostatistics, University of Washington, 325 9th Ave, Seattle, WA 98104, USADepartment of Epidemiology, University of Washington, 325 9th Ave, Seattle, WA 98104, USADepartment of Epidemiology, University of Washington, 325 9th Ave, Seattle, WA 98104, USAIn many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection alters unstimulated vaccine responses among HIV-1 infected individuals, we conducted two nested serologic studies. Blood samples were collected for HIV disease monitoring and vaccine-specific serologic assays, while stool was evaluated by direct microscopy methods. We compared antibody responses to measles and tetanus vaccines in helminth-infected (Ascaris, Trichuris, hookworm and/or Schistosoma mansoni) and uninfected adults 18 years and older (n = 100). We also compared measles and tetanus antibody responses in Ascaris only-infected adults receiving 400 mg albendazole daily for 3 days (n = 16) vs. placebo (n = 19) in a separate study. In both cohorts, over 70% of participants had measles and tetanus responses above the protective threshold. Prevalence of measles responses were similar between helminth-infected and uninfected individuals (82%, 95% CI: 71–93% vs 72%, 95% CI: 59–85%), as well as log10 tetanus antibody levels (−0.133 IU/mL vs −0.190 IU/mL, p > 0.05), and did not differ by helminth species. In the Ascaris-infected cohort, changes in measles responses and tetanus responses did not differ between those who received anthelminthic vs. placebo (p > 0.05 for both). In these studies, neither helminth infection, nor deworming, appeared to affect previously administered vaccine responsiveness in HIV-1 infected, ART naïve, adults in Kenya.http://www.sciencedirect.com/science/article/pii/S240567311630037XSoil-transmitted helminthHIVImmunizationVaccine preventable diseaseCo-infection |
| spellingShingle | Helen L. Storey Benson Singa Jackie Naulikha Helen Horton Barbra A. Richardson Grace John-Stewart Judd L. Walson Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults Parasite Epidemiology and Control Soil-transmitted helminth HIV Immunization Vaccine preventable disease Co-infection |
| title | Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults |
| title_full | Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults |
| title_fullStr | Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults |
| title_full_unstemmed | Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults |
| title_short | Soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among HIV-1 infected, ART naïve Kenyan adults |
| title_sort | soil transmitted helminth infections are not associated with compromised antibody responses to previously administered measles and tetanus vaccines among hiv 1 infected art naive kenyan adults |
| topic | Soil-transmitted helminth HIV Immunization Vaccine preventable disease Co-infection |
| url | http://www.sciencedirect.com/science/article/pii/S240567311630037X |
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