Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19
A 48-year-old female patient underwent a heart transplantation for acute fulminant myocarditis, following heterologous vaccination with the ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19. She had no history of severe acute respiratory syndrome coronavirus-2 infection. She did not exhibit clinical sign...
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MDPI AG
2022-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/3/449 |
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| author | Dong-Hoon Kang Joo-Young Na Jun-Ho Yang Seong-Ho Moon Sung-Hwan Kim Jae-Jun Jung Ho-Jeong Cha Jong-Hwa Ahn Yong-Whi Park Sang-Yeong Cho Ho-Kyung Yu Soo-Hee Lee Mi-Yeong Park Jong-Woo Kim Joung-Hun Byun |
| author_facet | Dong-Hoon Kang Joo-Young Na Jun-Ho Yang Seong-Ho Moon Sung-Hwan Kim Jae-Jun Jung Ho-Jeong Cha Jong-Hwa Ahn Yong-Whi Park Sang-Yeong Cho Ho-Kyung Yu Soo-Hee Lee Mi-Yeong Park Jong-Woo Kim Joung-Hun Byun |
| author_sort | Dong-Hoon Kang |
| collection | DOAJ |
| description | A 48-year-old female patient underwent a heart transplantation for acute fulminant myocarditis, following heterologous vaccination with the ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19. She had no history of severe acute respiratory syndrome coronavirus-2 infection. She did not exhibit clinical signs or have laboratory findings of concomitant infection before or after vaccination. Heart transplantation was performed because her heart failed to recover with venoarterial extracorporeal oxygenation support. Organ autopsy revealed giant cell myocarditis, possibly related to the vaccines. Clinicians may have to consider the possibility of the development of giant cell myocarditis, especially in patients with rapidly deteriorating cardiac function and myocarditis symptoms after COVID-19 vaccination. |
| first_indexed | 2024-03-09T13:22:57Z |
| format | Article |
| id | doaj.art-0690588427bb45f89f53eaced25f5f3c |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:22:57Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-0690588427bb45f89f53eaced25f5f3c2023-11-30T21:27:12ZengMDPI AGMedicina1010-660X1648-91442022-03-0158344910.3390/medicina58030449Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19Dong-Hoon Kang0Joo-Young Na1Jun-Ho Yang2Seong-Ho Moon3Sung-Hwan Kim4Jae-Jun Jung5Ho-Jeong Cha6Jong-Hwa Ahn7Yong-Whi Park8Sang-Yeong Cho9Ho-Kyung Yu10Soo-Hee Lee11Mi-Yeong Park12Jong-Woo Kim13Joung-Hun Byun14Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Forensic Medicine, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Internal Medicine, Gyeongsang National University College of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon 51472, KoreaDepartment of Internal Medicine, Gyeongsang National University College of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon 51472, KoreaDepartment of Internal Medicine, Gyeongsang National University College of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon 51472, KoreaDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon 51472, KoreaDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon 51472, KoreaDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon 51472, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaDepartment of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, KoreaA 48-year-old female patient underwent a heart transplantation for acute fulminant myocarditis, following heterologous vaccination with the ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19. She had no history of severe acute respiratory syndrome coronavirus-2 infection. She did not exhibit clinical signs or have laboratory findings of concomitant infection before or after vaccination. Heart transplantation was performed because her heart failed to recover with venoarterial extracorporeal oxygenation support. Organ autopsy revealed giant cell myocarditis, possibly related to the vaccines. Clinicians may have to consider the possibility of the development of giant cell myocarditis, especially in patients with rapidly deteriorating cardiac function and myocarditis symptoms after COVID-19 vaccination.https://www.mdpi.com/1648-9144/58/3/449COVID-19vaccinationgiant cell myocarditis |
| spellingShingle | Dong-Hoon Kang Joo-Young Na Jun-Ho Yang Seong-Ho Moon Sung-Hwan Kim Jae-Jun Jung Ho-Jeong Cha Jong-Hwa Ahn Yong-Whi Park Sang-Yeong Cho Ho-Kyung Yu Soo-Hee Lee Mi-Yeong Park Jong-Woo Kim Joung-Hun Byun Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 Medicina COVID-19 vaccination giant cell myocarditis |
| title | Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 |
| title_full | Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 |
| title_fullStr | Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 |
| title_full_unstemmed | Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 |
| title_short | Fulminant Giant Cell Myocarditis following Heterologous Vaccination of ChAdOx1 nCoV-19 and Pfizer-BioNTech COVID-19 |
| title_sort | fulminant giant cell myocarditis following heterologous vaccination of chadox1 ncov 19 and pfizer biontech covid 19 |
| topic | COVID-19 vaccination giant cell myocarditis |
| url | https://www.mdpi.com/1648-9144/58/3/449 |
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