Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxyg...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2020-03-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2020-0018 |
| _version_ | 1818460269866647552 |
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| author | Szweda Marta Rychlik Andrzej Babińska Izabella Pomianowski Andrzej |
| author_facet | Szweda Marta Rychlik Andrzej Babińska Izabella Pomianowski Andrzej |
| author_sort | Szweda Marta |
| collection | DOAJ |
| description | In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxygenase-2 (COX-2) is a promising biomarker with increasing relevance to human oncology, but as yet with less application in veterinary oncology. The expression of COX-2 increases significantly during pathological processes involving inflammation, pain or fever. It is also overexpressed in humans presenting various types of tumours and in selected types of tumours in animals, particularly in dogs. This article discusses the expression of COX-2 in canine and feline tumours, the importance of COX-2 as a biomarker with diagnostic, therapeutic, prognostic and predictive relevance in oncology, and the clinical significance of inhibiting COX-2 overexpression in tumours. |
| first_indexed | 2024-12-14T23:27:34Z |
| format | Article |
| id | doaj.art-069126e8849f4e33936e7a6381c31749 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-12-14T23:27:34Z |
| publishDate | 2020-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-069126e8849f4e33936e7a6381c317492022-12-21T22:43:46ZengSciendoJournal of Veterinary Research2450-86082020-03-0164115116010.2478/jvetres-2020-0018jvetres-2020-0018Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncologySzweda Marta0Rychlik Andrzej1Babińska Izabella2Pomianowski Andrzej3Department of Internal Diseases with Clinic, 10-719Olsztyn, PolandDepartment of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719Olsztyn, PolandDepartment of Pathophysiology, Forensic Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-718Olsztyn, PolandDepartment of Internal Diseases with Clinic, 10-719Olsztyn, PolandIn canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxygenase-2 (COX-2) is a promising biomarker with increasing relevance to human oncology, but as yet with less application in veterinary oncology. The expression of COX-2 increases significantly during pathological processes involving inflammation, pain or fever. It is also overexpressed in humans presenting various types of tumours and in selected types of tumours in animals, particularly in dogs. This article discusses the expression of COX-2 in canine and feline tumours, the importance of COX-2 as a biomarker with diagnostic, therapeutic, prognostic and predictive relevance in oncology, and the clinical significance of inhibiting COX-2 overexpression in tumours.https://doi.org/10.2478/jvetres-2020-0018dogcatbiomarkercox-2tumours |
| spellingShingle | Szweda Marta Rychlik Andrzej Babińska Izabella Pomianowski Andrzej Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology Journal of Veterinary Research dog cat biomarker cox-2 tumours |
| title | Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology |
| title_full | Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology |
| title_fullStr | Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology |
| title_full_unstemmed | Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology |
| title_short | Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology |
| title_sort | cyclooxygenase 2 as a biomarker with diagnostic therapeutic prognostic and predictive relevance in small animal oncology |
| topic | dog cat biomarker cox-2 tumours |
| url | https://doi.org/10.2478/jvetres-2020-0018 |
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