Erianin promotes endogenous neurogenesis in traumatic brain injury rats
Abstract The objective of this study was to explore the positive influence and potential mechanism of Erianin on the recovery of brain cells following a traumatic brain injury (TBI). TBI rat models were prepared and treated with Erianin injection via tail vein. The assessment included evaluating the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50573-8 |
| _version_ | 1797274840015568896 |
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| author | Qingquan Li Xiaokui Gan Ming Zhang Guangmin Zhang Yingbin Li Liang Gao |
| author_facet | Qingquan Li Xiaokui Gan Ming Zhang Guangmin Zhang Yingbin Li Liang Gao |
| author_sort | Qingquan Li |
| collection | DOAJ |
| description | Abstract The objective of this study was to explore the positive influence and potential mechanism of Erianin on the recovery of brain cells following a traumatic brain injury (TBI). TBI rat models were prepared and treated with Erianin injection via tail vein. The assessment included evaluating the rats' levels of oxidative stress, inflammation, neuronal damage, mitochondrial damage, neuronal regeneration, transformation of pro-inflammatory microglial cells, activation status of the ERK signal pathway, and the functionality of their learning and memory. After administering Erianin, there was a suppression of oxidative stress, inflammation, nerve cell damage, and mitochondrial damage in the TBI rats. Additionally, there was an increase in neuronal regeneration in the cortex and hippocampus, inhibition of pro-inflammatory microglial cell transformation in the cortex, improvement in learning and memory function in TBI rats, and simultaneous inhibition of the activation of the ERK1/c-Jun signal pathway. The findings suggest that Erianin has the potential to reduce oxidative stress and inflammatory reaction in rats with TBI, safeguard nerve cells against apoptosis, stimulate the growth of new neural cells, ultimately enhancing the cognitive abilities and memory function of the rats. The inhibition of the ERK signaling pathway could be closely associated with these effects. |
| first_indexed | 2024-03-07T15:04:53Z |
| format | Article |
| id | doaj.art-0692239c589c450c99819cfbb2d954fd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:04:53Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0692239c589c450c99819cfbb2d954fd2024-03-05T18:55:40ZengNature PortfolioScientific Reports2045-23222024-02-0114111110.1038/s41598-023-50573-8Erianin promotes endogenous neurogenesis in traumatic brain injury ratsQingquan Li0Xiaokui Gan1Ming Zhang2Guangmin Zhang3Yingbin Li4Liang Gao5Department of Neurosurgery, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Neurosurgery, Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Shanghai Tenth People’s Hospital Clinical Medical College, Nanjing Medical UniversityAbstract The objective of this study was to explore the positive influence and potential mechanism of Erianin on the recovery of brain cells following a traumatic brain injury (TBI). TBI rat models were prepared and treated with Erianin injection via tail vein. The assessment included evaluating the rats' levels of oxidative stress, inflammation, neuronal damage, mitochondrial damage, neuronal regeneration, transformation of pro-inflammatory microglial cells, activation status of the ERK signal pathway, and the functionality of their learning and memory. After administering Erianin, there was a suppression of oxidative stress, inflammation, nerve cell damage, and mitochondrial damage in the TBI rats. Additionally, there was an increase in neuronal regeneration in the cortex and hippocampus, inhibition of pro-inflammatory microglial cell transformation in the cortex, improvement in learning and memory function in TBI rats, and simultaneous inhibition of the activation of the ERK1/c-Jun signal pathway. The findings suggest that Erianin has the potential to reduce oxidative stress and inflammatory reaction in rats with TBI, safeguard nerve cells against apoptosis, stimulate the growth of new neural cells, ultimately enhancing the cognitive abilities and memory function of the rats. The inhibition of the ERK signaling pathway could be closely associated with these effects.https://doi.org/10.1038/s41598-023-50573-8 |
| spellingShingle | Qingquan Li Xiaokui Gan Ming Zhang Guangmin Zhang Yingbin Li Liang Gao Erianin promotes endogenous neurogenesis in traumatic brain injury rats Scientific Reports |
| title | Erianin promotes endogenous neurogenesis in traumatic brain injury rats |
| title_full | Erianin promotes endogenous neurogenesis in traumatic brain injury rats |
| title_fullStr | Erianin promotes endogenous neurogenesis in traumatic brain injury rats |
| title_full_unstemmed | Erianin promotes endogenous neurogenesis in traumatic brain injury rats |
| title_short | Erianin promotes endogenous neurogenesis in traumatic brain injury rats |
| title_sort | erianin promotes endogenous neurogenesis in traumatic brain injury rats |
| url | https://doi.org/10.1038/s41598-023-50573-8 |
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