Engineering ER-stress dependent non-conventional mRNA splicing

Engineering ER-stress dependent non-conventional mRNA splicing

The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding burden to prevent accumulation of un- or misfolded proteins. The ER membrane-resident kinase/RNase Ire1 maintains ER protein homeostasis through two fundamentally distinct processes. First, Ire1 can initiate...

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Bibliographic Details
Main Authors: Weihan Li, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Meghan Zubradt, Jonathan S Weissman, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
unfolded protein response
RNA processing
non-conventional mRNA splicing
evolutionary biology
Online Access:https://elifesciences.org/articles/35388

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