Circ_0045714/miR-331-3p interaction affects IL-1β-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade

Circ_0045714/miR-331-3p interaction affects IL-1β-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade

Abstract Background Osteoarthritis (OA) is characterized by joint pain and joint function limitation. Hsa_circ_0045714 (circ_0045714) is a novel OA-related circular RNA. However, its repertoire remains to be further clarified in joint chondrocytes. Methods RNA and protein expression levels and infla...

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Bibliographic Details
Main Authors: Ran Ding, Jinsong Zhou, Jianguo Xu, Huajie Lu, Tingting Zhang, Xiong Xiang, Zhen Shi
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Circ_0045714
miR-331-3p
PIK3R3
IL-1β
Human articular chondrocytes
Osteoarthritis
Online Access:https://doi.org/10.1186/s13018-021-02738-2

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