Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients
Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-12-01
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| Series: | Balkan Journal of Medical Genetics |
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| Online Access: | https://doi.org/10.1515/bjmg-2017-0033 |
| _version_ | 1797761216695762944 |
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| author | Tuna A Ozturk G Gerceker TB Karaca E Onay H Guvenc SM Cogulu O |
| author_facet | Tuna A Ozturk G Gerceker TB Karaca E Onay H Guvenc SM Cogulu O |
| author_sort | Tuna A |
| collection | DOAJ |
| description | Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A/C and SOD2 A16V (C/T) polymorphism allele frequencies were compared by using χ2 tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C/T) polymorphism, a significant difference was determined for the distribution of the genotypes [p = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients. |
| first_indexed | 2024-03-12T19:09:45Z |
| format | Article |
| id | doaj.art-069636582f5c443c91e657eafa9e9594 |
| institution | Directory Open Access Journal |
| issn | 1311-0160 |
| language | English |
| last_indexed | 2024-03-12T19:09:45Z |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-069636582f5c443c91e657eafa9e95942023-08-02T05:57:35ZengSciendoBalkan Journal of Medical Genetics1311-01602017-12-01202677310.1515/bjmg-2017-0033bjmg-2017-0033Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patientsTuna A0Ozturk G1Gerceker TB2Karaca E3Onay H4Guvenc SM5Cogulu O6Department of Dermatology and Venerology, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Dermatology and Venerology, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Dermatology and Venerology, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Genetics, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Genetics, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Genetics, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Genetics, Faculty of Medicine, Ege University, Izmir, TurkeyVitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A/C and SOD2 A16V (C/T) polymorphism allele frequencies were compared by using χ2 tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C/T) polymorphism, a significant difference was determined for the distribution of the genotypes [p = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients.https://doi.org/10.1515/bjmg-2017-0033sod1sod2superoxide dismutase (sod)vitiligo |
| spellingShingle | Tuna A Ozturk G Gerceker TB Karaca E Onay H Guvenc SM Cogulu O Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients Balkan Journal of Medical Genetics sod1 sod2 superoxide dismutase (sod) vitiligo |
| title | Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients |
| title_full | Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients |
| title_fullStr | Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients |
| title_full_unstemmed | Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients |
| title_short | Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients |
| title_sort | superoxide dismutase 1 and 2 gene polymorphism in turkish vitiligo patients |
| topic | sod1 sod2 superoxide dismutase (sod) vitiligo |
| url | https://doi.org/10.1515/bjmg-2017-0033 |
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