Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice
Abstract Background This study aimed to assess the single-dose toxicity of THJ-2201 by hematological and histopathological evaluation of liver and kidney specimens in Swiss albino mice. The experimental protocol included oral treatment of mice with different doses (5, 50, 300, 2000 mg/kg body weight...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-08-01
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| Series: | Egyptian Journal of Forensic Sciences |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41935-018-0079-1 |
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| author | Abdulsallam Bakdash Ahmad Mohamed Khir AL-Mathloum Elkhatim H. Abdelgadir ElAmin Nael M. T. Abu Taha Sachil Kumar Fahd Ali Nasr |
| author_facet | Abdulsallam Bakdash Ahmad Mohamed Khir AL-Mathloum Elkhatim H. Abdelgadir ElAmin Nael M. T. Abu Taha Sachil Kumar Fahd Ali Nasr |
| author_sort | Abdulsallam Bakdash |
| collection | DOAJ |
| description | Abstract Background This study aimed to assess the single-dose toxicity of THJ-2201 by hematological and histopathological evaluation of liver and kidney specimens in Swiss albino mice. The experimental protocol included oral treatment of mice with different doses (5, 50, 300, 2000 mg/kg body weight of THJ-2201) for 24 h. At the end of the treatment, blood samples had been drawn, and renal and hepatic tissues have been excised from the experimental mice groups for hematological and histological examinations. Results Results showed that dose-dependent treatment with THJ-2201 leads to mild tremor clinical signs with low doses and photophobia (sensitivity to light) and even cessation of breathing as a potential cause of death with high doses in treated mice. Conclusion The LD50 value of THJ-2201 was 822.20 mg/kg, which is considered as a chemical compound of low toxicity. Histological studies confirmed that liver and kidney toxicities have been manifested in the findings of congestion, necrosis, inflammation, and bleeding within the liver and to lesser extent in the kidneys. |
| first_indexed | 2024-12-23T14:57:23Z |
| format | Article |
| id | doaj.art-069894e06f494828bed0713be0f412b1 |
| institution | Directory Open Access Journal |
| issn | 2090-5939 |
| language | English |
| last_indexed | 2024-12-23T14:57:23Z |
| publishDate | 2018-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Forensic Sciences |
| spelling | doaj.art-069894e06f494828bed0713be0f412b12022-12-21T17:42:43ZengSpringerOpenEgyptian Journal of Forensic Sciences2090-59392018-08-01811610.1186/s41935-018-0079-1Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in miceAbdulsallam Bakdash0Ahmad Mohamed Khir AL-Mathloum1Elkhatim H. Abdelgadir ElAmin2Nael M. T. Abu Taha3Sachil Kumar4Fahd Ali Nasr5Department of Forensic Chemistry, College of Forensic Sciences, Naif Arab University for Security SciencesDepartment of Forensic Chemistry, College of Forensic Sciences, Naif Arab University for Security SciencesDepartment of Forensic Chemistry, College of Forensic Sciences, Naif Arab University for Security SciencesBio products Research Chair (BRC), College of Science, King Saud UniversityArab Society for Forensic Sciences and Forensic Medicine, Naif Arab University for Security SciencesBio products Research Chair (BRC), College of Science, King Saud UniversityAbstract Background This study aimed to assess the single-dose toxicity of THJ-2201 by hematological and histopathological evaluation of liver and kidney specimens in Swiss albino mice. The experimental protocol included oral treatment of mice with different doses (5, 50, 300, 2000 mg/kg body weight of THJ-2201) for 24 h. At the end of the treatment, blood samples had been drawn, and renal and hepatic tissues have been excised from the experimental mice groups for hematological and histological examinations. Results Results showed that dose-dependent treatment with THJ-2201 leads to mild tremor clinical signs with low doses and photophobia (sensitivity to light) and even cessation of breathing as a potential cause of death with high doses in treated mice. Conclusion The LD50 value of THJ-2201 was 822.20 mg/kg, which is considered as a chemical compound of low toxicity. Histological studies confirmed that liver and kidney toxicities have been manifested in the findings of congestion, necrosis, inflammation, and bleeding within the liver and to lesser extent in the kidneys.http://link.springer.com/article/10.1186/s41935-018-0079-1Forensic scienceTHJ-2201LD50CannabinoidsToxicityMice |
| spellingShingle | Abdulsallam Bakdash Ahmad Mohamed Khir AL-Mathloum Elkhatim H. Abdelgadir ElAmin Nael M. T. Abu Taha Sachil Kumar Fahd Ali Nasr Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice Egyptian Journal of Forensic Sciences Forensic science THJ-2201 LD50 Cannabinoids Toxicity Mice |
| title | Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice |
| title_full | Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice |
| title_fullStr | Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice |
| title_full_unstemmed | Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice |
| title_short | Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice |
| title_sort | single dose acute toxicity of thj 2201 designer cannabis drug ld50 and hematological and histological changes in mice |
| topic | Forensic science THJ-2201 LD50 Cannabinoids Toxicity Mice |
| url | http://link.springer.com/article/10.1186/s41935-018-0079-1 |
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