Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review
Cancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical vari...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2023-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300041M.pdf |
| _version_ | 1797393646399520768 |
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| author | Manojmouli Chandramouli Pasha Thoppalada Yunus Nagaprashant Koppuravuri Ramesh Beevinahalli Ul Eain Noor Purushotham Kardigere Nagaraju |
| author_facet | Manojmouli Chandramouli Pasha Thoppalada Yunus Nagaprashant Koppuravuri Ramesh Beevinahalli Ul Eain Noor Purushotham Kardigere Nagaraju |
| author_sort | Manojmouli Chandramouli |
| collection | DOAJ |
| description | Cancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical variability. Among the various natural metabolites, flavonoids are secondary metabolites that are extensively present in nature, have potent anti-cancer properties, have few adverse effects, and also show synergistic benefits. Numerous laboratories are diligently investigating the chemistry and biology of novel flavonoid derivatives due to the demand for and value of these drugs. In this survay, we have summarized clinical trials of various flavonoids, molecular pathways against various cancer cell lines and recent updates on the anticancer activity of flavonoid derivatives against various cancer cells synthesized by various methods, more studies are needed to develop the following mentioned flavonoid derivatives as an anticancer drug. |
| first_indexed | 2024-03-09T00:06:49Z |
| format | Article |
| id | doaj.art-0698c1f5f6c04fca87a2298244f09ecb |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-03-09T00:06:49Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-0698c1f5f6c04fca87a2298244f09ecb2023-12-12T13:08:14ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212023-01-01881093795710.2298/JSC221228041M0352-51392300041MFlavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated reviewManojmouli Chandramouli0https://orcid.org/0000-0001-8850-7110Pasha Thoppalada Yunus1https://orcid.org/0000-0003-0385-3343Nagaprashant Koppuravuri2https://orcid.org/0000-0002-2551-234XRamesh Beevinahalli3https://orcid.org/0000-0003-3269-3094Ul Eain Noor4https://orcid.org/0000-0003-2367-5425Purushotham Kardigere Nagaraju5https://orcid.org/0000-0001-8643-7083Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G. Nagara, Karnataka, IndiaCancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical variability. Among the various natural metabolites, flavonoids are secondary metabolites that are extensively present in nature, have potent anti-cancer properties, have few adverse effects, and also show synergistic benefits. Numerous laboratories are diligently investigating the chemistry and biology of novel flavonoid derivatives due to the demand for and value of these drugs. In this survay, we have summarized clinical trials of various flavonoids, molecular pathways against various cancer cell lines and recent updates on the anticancer activity of flavonoid derivatives against various cancer cells synthesized by various methods, more studies are needed to develop the following mentioned flavonoid derivatives as an anticancer drug.https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300041M.pdfflavonoidscancerchemotherapymolecular targets |
| spellingShingle | Manojmouli Chandramouli Pasha Thoppalada Yunus Nagaprashant Koppuravuri Ramesh Beevinahalli Ul Eain Noor Purushotham Kardigere Nagaraju Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review Journal of the Serbian Chemical Society flavonoids cancer chemotherapy molecular targets |
| title | Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review |
| title_full | Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review |
| title_fullStr | Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review |
| title_full_unstemmed | Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review |
| title_short | Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review |
| title_sort | flavonoid derivatives as anticancer moiety and its effect on cancer cell lines an updated review |
| topic | flavonoids cancer chemotherapy molecular targets |
| url | https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300041M.pdf |
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