The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence.
There is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disease interventions such as vaccination may lead to evolution of more harmful parasites. A new study published in PLOS B...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-08-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC4548947?pdf=render |
| _version_ | 1819139776373063680 |
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| author | Mike Boots |
| author_facet | Mike Boots |
| author_sort | Mike Boots |
| collection | DOAJ |
| description | There is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disease interventions such as vaccination may lead to evolution of more harmful parasites. A new study published in PLOS Biology by Andrew Read and colleagues shows empirically that vaccination against Marek's disease has favored higher virulence; without intervention, the birds die too quickly for any transmission to occur, but vaccinated hosts can both stay alive longer and shed the virus. This is an elegant empirical demonstration of how evolutionary theory can predict potentially dangerous responses of infectious disease to human interventions. |
| first_indexed | 2024-12-22T11:28:02Z |
| format | Article |
| id | doaj.art-0699b1adc4fa4a18954fc1b5c91b1fb6 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-22T11:28:02Z |
| publishDate | 2015-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-0699b1adc4fa4a18954fc1b5c91b1fb62022-12-21T18:27:41ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852015-08-01138e100223610.1371/journal.pbio.1002236The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence.Mike BootsThere is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disease interventions such as vaccination may lead to evolution of more harmful parasites. A new study published in PLOS Biology by Andrew Read and colleagues shows empirically that vaccination against Marek's disease has favored higher virulence; without intervention, the birds die too quickly for any transmission to occur, but vaccinated hosts can both stay alive longer and shed the virus. This is an elegant empirical demonstration of how evolutionary theory can predict potentially dangerous responses of infectious disease to human interventions.http://europepmc.org/articles/PMC4548947?pdf=render |
| spellingShingle | Mike Boots The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence. PLoS Biology |
| title | The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence. |
| title_full | The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence. |
| title_fullStr | The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence. |
| title_full_unstemmed | The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence. |
| title_short | The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence. |
| title_sort | need for evolutionarily rational disease interventions vaccination can select for higher virulence |
| url | http://europepmc.org/articles/PMC4548947?pdf=render |
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