The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota
Sexual dimorphism is an important factor in understanding various diseases, including inflammatory bowel disease (IBD). While females typically exhibit stronger immune responses, the role of sex in IBD remains unclear. This study aimed to explore the sex-dependent differences and inflammatory suscep...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10364 |
| _version_ | 1797594253211205632 |
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| author | Maite Casado-Bedmar Maryline Roy Emilie Viennois |
| author_facet | Maite Casado-Bedmar Maryline Roy Emilie Viennois |
| author_sort | Maite Casado-Bedmar |
| collection | DOAJ |
| description | Sexual dimorphism is an important factor in understanding various diseases, including inflammatory bowel disease (IBD). While females typically exhibit stronger immune responses, the role of sex in IBD remains unclear. This study aimed to explore the sex-dependent differences and inflammatory susceptibility in the most extensively used IBD mouse model as they developed colitis. We monitored IL10-deficient mice (IL-10<sup>−/−</sup>) up to 17 weeks of age and characterized their colonic and fecal inflammatory phenotype, as well as their microbiota changes. Here, we originally identified IL-10<sup>−/−</sup> female mice as more prone to developing intestinal inflammation, with an increase in fecal miR-21, and dysbiosis with more detrimental characteristics compared to males. Our findings provide valuable insights into the sex-based differences in the pathophysiology of colitis and emphasize the importance of considering sex in experimental designs. Moreover, this study paves the way for future investigations aiming at addressing sex-related differences for the development of adequate disease models and therapeutic strategies, ideally enabling personalized medicine. |
| first_indexed | 2024-03-11T02:20:00Z |
| format | Article |
| id | doaj.art-069a1050d0f046d59c876f80a3eb433a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:20:00Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-069a1050d0f046d59c876f80a3eb433a2023-11-18T10:52:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121036410.3390/ijms241210364The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and MicrobiotaMaite Casado-Bedmar0Maryline Roy1Emilie Viennois2INSERM, U1149, Center of Research on Inflammation, Université de Paris, 75018 Paris, FranceINSERM, U1149, Center of Research on Inflammation, Université de Paris, 75018 Paris, FranceINSERM, U1149, Center of Research on Inflammation, Université de Paris, 75018 Paris, FranceSexual dimorphism is an important factor in understanding various diseases, including inflammatory bowel disease (IBD). While females typically exhibit stronger immune responses, the role of sex in IBD remains unclear. This study aimed to explore the sex-dependent differences and inflammatory susceptibility in the most extensively used IBD mouse model as they developed colitis. We monitored IL10-deficient mice (IL-10<sup>−/−</sup>) up to 17 weeks of age and characterized their colonic and fecal inflammatory phenotype, as well as their microbiota changes. Here, we originally identified IL-10<sup>−/−</sup> female mice as more prone to developing intestinal inflammation, with an increase in fecal miR-21, and dysbiosis with more detrimental characteristics compared to males. Our findings provide valuable insights into the sex-based differences in the pathophysiology of colitis and emphasize the importance of considering sex in experimental designs. Moreover, this study paves the way for future investigations aiming at addressing sex-related differences for the development of adequate disease models and therapeutic strategies, ideally enabling personalized medicine.https://www.mdpi.com/1422-0067/24/12/10364IBDmicrobiotacolitisInterleukin-10mouse modelIL-10 knockout mice |
| spellingShingle | Maite Casado-Bedmar Maryline Roy Emilie Viennois The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota International Journal of Molecular Sciences IBD microbiota colitis Interleukin-10 mouse model IL-10 knockout mice |
| title | The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota |
| title_full | The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota |
| title_fullStr | The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota |
| title_full_unstemmed | The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota |
| title_short | The Effect of Sex-Specific Differences on IL-10<sup>−/−</sup> Mouse Colitis Phenotype and Microbiota |
| title_sort | effect of sex specific differences on il 10 sup sup mouse colitis phenotype and microbiota |
| topic | IBD microbiota colitis Interleukin-10 mouse model IL-10 knockout mice |
| url | https://www.mdpi.com/1422-0067/24/12/10364 |
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