Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study
Purpose: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. Methods: A total of 159 men (≥50 years of age) with lower urinary tract sympto...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2015-06-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-19-2-107.pdf |
| _version_ | 1818335639632871424 |
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| author | Sung Gon Park Byung Ha Chung Sung Won Lee Jong Kwan Park Kwangsung Park Jun Cheon Kyung Seop Lee Hyung-Jee Kim Do-Hwan Seong Seung-June Oh Sae Woong Kim Ji Youl Lee Seol Ho Choo Jong Bo Choi |
| author_facet | Sung Gon Park Byung Ha Chung Sung Won Lee Jong Kwan Park Kwangsung Park Jun Cheon Kyung Seop Lee Hyung-Jee Kim Do-Hwan Seong Seung-June Oh Sae Woong Kim Ji Youl Lee Seol Ho Choo Jong Bo Choi |
| author_sort | Sung Gon Park |
| collection | DOAJ |
| description | Purpose: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. Methods: A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline. Results: Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower. Conclusions: The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group. |
| first_indexed | 2024-12-13T14:26:38Z |
| format | Article |
| id | doaj.art-069b05fdf55e4501bcd486423a4bb492 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-13T14:26:38Z |
| publishDate | 2015-06-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-069b05fdf55e4501bcd486423a4bb4922022-12-21T23:41:55ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312015-06-0119210711210.5213/inj.2015.19.2.107529Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational StudySung Gon Park0Byung Ha Chung1Sung Won Lee2Jong Kwan Park3Kwangsung Park4Jun Cheon5Kyung Seop Lee6Hyung-Jee Kim7Do-Hwan Seong8Seung-June Oh9Sae Woong Kim10Ji Youl Lee11Seol Ho Choo12Jong Bo Choi13 Department of Urology, Ajou University School of Medicine, Suwon, Korea Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Urology, Chonbuk National University Medical School, Jeonju, Korea Department of Urology, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Korea University Anam Hospital, Seoul, Korea Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea Department of Urology, Dankook University College of Medicine, Cheonan, Korea Department of Urology, Inha University College of Medicine, Incheon, Korea Department of Urology, Seoul National University Hospital, Seoul, Korea Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Urology, Ajou University School of Medicine, Suwon, Korea Department of Urology, Ajou University School of Medicine, Suwon, KoreaPurpose: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. Methods: A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline. Results: Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower. Conclusions: The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group.http://www.einj.org/upload/pdf/inj-19-2-107.pdfHeart RateProstatic HyperplasiaSympathetic Nervous SystemLower Urinary Tract Symptoms |
| spellingShingle | Sung Gon Park Byung Ha Chung Sung Won Lee Jong Kwan Park Kwangsung Park Jun Cheon Kyung Seop Lee Hyung-Jee Kim Do-Hwan Seong Seung-June Oh Sae Woong Kim Ji Youl Lee Seol Ho Choo Jong Bo Choi Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study International Neurourology Journal Heart Rate Prostatic Hyperplasia Sympathetic Nervous System Lower Urinary Tract Symptoms |
| title | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
| title_full | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
| title_fullStr | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
| title_full_unstemmed | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
| title_short | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
| title_sort | alpha blocker treatment response in men with lower urinary tract symptoms based on sympathetic activity prospective multicenter open labeled observational study |
| topic | Heart Rate Prostatic Hyperplasia Sympathetic Nervous System Lower Urinary Tract Symptoms |
| url | http://www.einj.org/upload/pdf/inj-19-2-107.pdf |
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