Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose-Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model

Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose-Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model

Cysteine proteases obtained from the stem of pineapple or papaya latex, bromelain and papain, respectively, exhibit a broad spectrum of beneficial effects on human health. However, their effects on gut microbiota composition or dose-manner effects on the intestinal integrity of healthy tissue have n...

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Bibliographic Details
Main Authors: Olha Kostiuchenko, Nadiia Kravchenko, Jan Markus, Stephen Burleigh, Olexandr Fedkiv, Ling Cao, Silvia Letasiova, Galyna Skibo, Frida Fåk Hållenius, Olena Prykhodko
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Metabolites
Subjects:
bromelain
papain
trypsin
<i>Akkermansia muciniphila</i>
intestinal integrity
Online Access:https://www.mdpi.com/2218-1989/12/11/1027

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