Covalent Organic Framework (COF): A Drug and Carrier to Attenuate Retinal Ganglion Cells Death in an Acute Glaucoma Mouse Model

Covalent Organic Framework (COF): A Drug and Carrier to Attenuate Retinal Ganglion Cells Death in an Acute Glaucoma Mouse Model

Purpose: We aim to investigate the use of covalent organic framework (COF) nanoparticles in the local treatment of glaucoma, both as a means of protecting retinal ganglion cells (RGCs), and as a carrier for delayed release of the medication rapamycin following a single intravitreal injection. Method...

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Bibliographic Details
Main Authors: Ke Yao, Xin Liang, Guiyang Zhang, Yan Rong, Qiuxiang Zhang, Qiaobo Liao, Hong Zhang, Kai Xi, Junming Wang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Polymers
Subjects:
covalent organic framework
rapamycin
retinal ischemia–reperfusion
glaucoma
Online Access:https://www.mdpi.com/2073-4360/14/16/3265

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