Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging
To review the role of inflammation in the occurrence and development of benign prostatic hyperplasia (BPH), we searched PubMed for the latest published articles up to February 2021 using the following key words: “benign prostatic hyperplasia”, “inflammation”, “pathogenesis” and “disease development”...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.842008/full |
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| author | Dehong Cao Dehong Cao Ruonan Sun Ruonan Sun Ruonan Sun Lei Peng Jinze Li Jinze Li Yin Huang Yin Huang Yin Huang Zeyu Chen Zeyu Chen Zeyu Chen Bo Chen Bo Chen Bo Chen Jin Li Jin Li Jin Li Jianzhong Ai Jianzhong Ai Lu Yang Lu Yang Liangren Liu Liangren Liu Qiang Wei Qiang Wei |
| author_facet | Dehong Cao Dehong Cao Ruonan Sun Ruonan Sun Ruonan Sun Lei Peng Jinze Li Jinze Li Yin Huang Yin Huang Yin Huang Zeyu Chen Zeyu Chen Zeyu Chen Bo Chen Bo Chen Bo Chen Jin Li Jin Li Jin Li Jianzhong Ai Jianzhong Ai Lu Yang Lu Yang Liangren Liu Liangren Liu Qiang Wei Qiang Wei |
| author_sort | Dehong Cao |
| collection | DOAJ |
| description | To review the role of inflammation in the occurrence and development of benign prostatic hyperplasia (BPH), we searched PubMed for the latest published articles up to February 2021 using the following key words: “benign prostatic hyperplasia”, “inflammation”, “pathogenesis” and “disease development”. Articles were obtained and reviewed to provide a systematic review of the current progress of the role of inflammation in the pathogenesis and progression of BPH. Inflammation contributes to the initiation and maintenance of unregulated cell proliferation and is closely related to the occurrence and development of BPH. Its action pathways include tissue damage and subsequent chronic healing, autoimmunity, and coaction with androgens. During the progression of inflammation, macrophages, interleukin-8 (IL-8), interleukin-1 (IL-1) and other inflammatory-related substances aggregate locally and cause BPH through various biochemical pathways. At the same time, BPH can also counteract inflammation to expand its scope and aggravate the situation. Inflammation can independently affect the development of BPH in a variety of ways, and it can also interact with androgens. In the course of treatment, early intervention in the occurrence and development of inflammation in prostate tissue can slow down the progression of BPH. The combination of standard therapies and anti-inflammatory measures may provide valuable new ideas for the treatment of BPH. |
| first_indexed | 2024-12-14T18:45:29Z |
| format | Article |
| id | doaj.art-06a0725393d84ed0afd4f9e13d318660 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T18:45:29Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-06a0725393d84ed0afd4f9e13d3186602022-12-21T22:51:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.842008842008Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in AgingDehong Cao0Dehong Cao1Ruonan Sun2Ruonan Sun3Ruonan Sun4Lei Peng5Jinze Li6Jinze Li7Yin Huang8Yin Huang9Yin Huang10Zeyu Chen11Zeyu Chen12Zeyu Chen13Bo Chen14Bo Chen15Bo Chen16Jin Li17Jin Li18Jin Li19Jianzhong Ai20Jianzhong Ai21Lu Yang22Lu Yang23Liangren Liu24Liangren Liu25Qiang Wei26Qiang Wei27Department of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaTo review the role of inflammation in the occurrence and development of benign prostatic hyperplasia (BPH), we searched PubMed for the latest published articles up to February 2021 using the following key words: “benign prostatic hyperplasia”, “inflammation”, “pathogenesis” and “disease development”. Articles were obtained and reviewed to provide a systematic review of the current progress of the role of inflammation in the pathogenesis and progression of BPH. Inflammation contributes to the initiation and maintenance of unregulated cell proliferation and is closely related to the occurrence and development of BPH. Its action pathways include tissue damage and subsequent chronic healing, autoimmunity, and coaction with androgens. During the progression of inflammation, macrophages, interleukin-8 (IL-8), interleukin-1 (IL-1) and other inflammatory-related substances aggregate locally and cause BPH through various biochemical pathways. At the same time, BPH can also counteract inflammation to expand its scope and aggravate the situation. Inflammation can independently affect the development of BPH in a variety of ways, and it can also interact with androgens. In the course of treatment, early intervention in the occurrence and development of inflammation in prostate tissue can slow down the progression of BPH. The combination of standard therapies and anti-inflammatory measures may provide valuable new ideas for the treatment of BPH.https://www.frontiersin.org/articles/10.3389/fimmu.2022.842008/fullbenign prostatic hyperplasiapathogenesisdisease progressionaginginflammation |
| spellingShingle | Dehong Cao Dehong Cao Ruonan Sun Ruonan Sun Ruonan Sun Lei Peng Jinze Li Jinze Li Yin Huang Yin Huang Yin Huang Zeyu Chen Zeyu Chen Zeyu Chen Bo Chen Bo Chen Bo Chen Jin Li Jin Li Jin Li Jianzhong Ai Jianzhong Ai Lu Yang Lu Yang Liangren Liu Liangren Liu Qiang Wei Qiang Wei Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging Frontiers in Immunology benign prostatic hyperplasia pathogenesis disease progression aging inflammation |
| title | Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging |
| title_full | Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging |
| title_fullStr | Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging |
| title_full_unstemmed | Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging |
| title_short | Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging |
| title_sort | immune cell proinflammatory microenvironment and androgen related metabolic regulation during benign prostatic hyperplasia in aging |
| topic | benign prostatic hyperplasia pathogenesis disease progression aging inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.842008/full |
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