The potential roles of JAK/STAT signaling in the progression of osteoarthritis
Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an im...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1069057/full |
| _version_ | 1811179751678672896 |
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| author | Qingluo Zhou Qun Ren Linhui Jiao Jishang Huang Jun Yi Jincai Chen Jinliang Lai Guanglin Ji Tiansheng Zheng |
| author_facet | Qingluo Zhou Qun Ren Linhui Jiao Jishang Huang Jun Yi Jincai Chen Jinliang Lai Guanglin Ji Tiansheng Zheng |
| author_sort | Qingluo Zhou |
| collection | DOAJ |
| description | Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA. |
| first_indexed | 2024-04-11T06:38:50Z |
| format | Article |
| id | doaj.art-06a1defa8adb42599f40d6076d6154f6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T06:38:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-06a1defa8adb42599f40d6076d6154f62022-12-22T04:39:35ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10690571069057The potential roles of JAK/STAT signaling in the progression of osteoarthritisQingluo Zhou0Qun Ren1Linhui Jiao2Jishang Huang3Jun Yi4Jincai Chen5Jinliang Lai6Guanglin Ji7Tiansheng Zheng8Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou, ChinaCollege of Pharmacy, Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaOsteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA.https://www.frontiersin.org/articles/10.3389/fendo.2022.1069057/fullosteoarthritisJAK/STAT pathwayinflammationcartilage remodelingSOCS |
| spellingShingle | Qingluo Zhou Qun Ren Linhui Jiao Jishang Huang Jun Yi Jincai Chen Jinliang Lai Guanglin Ji Tiansheng Zheng The potential roles of JAK/STAT signaling in the progression of osteoarthritis Frontiers in Endocrinology osteoarthritis JAK/STAT pathway inflammation cartilage remodeling SOCS |
| title | The potential roles of JAK/STAT signaling in the progression of osteoarthritis |
| title_full | The potential roles of JAK/STAT signaling in the progression of osteoarthritis |
| title_fullStr | The potential roles of JAK/STAT signaling in the progression of osteoarthritis |
| title_full_unstemmed | The potential roles of JAK/STAT signaling in the progression of osteoarthritis |
| title_short | The potential roles of JAK/STAT signaling in the progression of osteoarthritis |
| title_sort | potential roles of jak stat signaling in the progression of osteoarthritis |
| topic | osteoarthritis JAK/STAT pathway inflammation cartilage remodeling SOCS |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1069057/full |
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