Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population
Background: Patients with pollinosis are often multi-sensitized to diverse pollen allergens. However, little is known about pollen allergy types among Chinese pollinosis patients. This study is aimed to characterize clinical manifestations of food allergy among patients with different types of polle...
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| Format: | Article |
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Elsevier
2020-05-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455120300235 |
| _version_ | 1818144140124225536 |
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| author | Jun-Da Li Zhi-Rong Du Juan Liu Ying-Yang Xu Rui-Qi Wang Jia Yin |
| author_facet | Jun-Da Li Zhi-Rong Du Juan Liu Ying-Yang Xu Rui-Qi Wang Jia Yin |
| author_sort | Jun-Da Li |
| collection | DOAJ |
| description | Background: Patients with pollinosis are often multi-sensitized to diverse pollen allergens. However, little is known about pollen allergy types among Chinese pollinosis patients. This study is aimed to characterize clinical manifestations of food allergy among patients with different types of pollen allergy. Methods: We retrospectively analyzed 402 pollinosis patients from an outpatient allergy department of the Peking Union Medical College Hospital who had been diagnosed by experienced allergists. All included patients who answered a questionnaire regarding seasonal pollinosis and clinical symptoms after ingestion of food and underwent intradermal skin tests. Total IgE and specific IgE levels were quantified by ImmunoCAP, using 0.35 kUA/L as a threshold for positivity. Results: The patients were divided into 3 groups, based on the season during which they experienced symptoms and the 2 peaks of Chinese airborne pollen: spring-tree pollen symptoms group (SG), autumn-weed pollen symptoms group (AG), and a combined spring and autumn pollen symptoms group (CG). Birch pollen (83%) and ash pollen (74%) were common allergens among patients with spring symptoms, while mugwort pollen (87%) was a common allergen among patients with autumn symptoms. In total, 30% of the study population experienced pollen-related food allergy. Pollen-related food allergies were more prevalent among the single-season symptom groups (68% and 50% for the SG and AG, respectively) than among the CG (20%). All patients with pollen-related food-induced anaphylaxis exhibited autumn weed pollen symptoms. Except for 2 patients, all patients with food-induced anaphylaxis were allergic to mugwort pollen. In the SG, all patients with food allergy were sensitive to birch pollen, with birch and Bet v 1-specific IgE levels higher in this group than in the group without food allergy (p < 0.001). In the AG, Art v 3 was more prevalent among patients with pollen-related food allergy than without food allergy (79% vs. 33%, p < 0.001), a proportion similar to the one in the CG (67% vs. 48%, p = 0.01). Meanwhile, the Art v 3-specific IgE levels among patients with pollen-related food allergy were higher than among tolerant patients in the AG (p < 0.001) and CG (p = 0.02). Unexpectedly, the Art v 3-specific IgE levels were higher in patients with food-induced anaphylaxis than with oral allergy syndrome only in the CG. Conclusions: Bet v 1 (a Pathogenesis-related 10 protein) and Art v 3 (a non-specific lipid transfer protein; nsLTP) are candidate molecular biomarkers for the diagnosis of food allergies in patients with season-specific pollen-related allergies. Measuring pollen allergen component-specific IgE levels might be an effective tool for the management of pollinosis in clinical practice in China. |
| first_indexed | 2024-12-11T11:42:49Z |
| format | Article |
| id | doaj.art-06a2a9cdc4874fa6a585a5e7e7fa4000 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-11T11:42:49Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-06a2a9cdc4874fa6a585a5e7e7fa40002022-12-22T01:08:34ZengElsevierWorld Allergy Organization Journal1939-45512020-05-01135Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese populationJun-Da Li0Zhi-Rong Du1Juan Liu2Ying-Yang Xu3Rui-Qi Wang4Jia Yin5Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China; National Clinical Research Center for Dermatologic and Immunologic Disease, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China; National Clinical Research Center for Dermatologic and Immunologic Disease, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China; National Clinical Research Center for Dermatologic and Immunologic Disease, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China; National Clinical Research Center for Dermatologic and Immunologic Disease, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China; National Clinical Research Center for Dermatologic and Immunologic Disease, ChinaDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, China; National Clinical Research Center for Dermatologic and Immunologic Disease, China; Corresponding author. Department of Allergy, Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, ChinaBackground: Patients with pollinosis are often multi-sensitized to diverse pollen allergens. However, little is known about pollen allergy types among Chinese pollinosis patients. This study is aimed to characterize clinical manifestations of food allergy among patients with different types of pollen allergy. Methods: We retrospectively analyzed 402 pollinosis patients from an outpatient allergy department of the Peking Union Medical College Hospital who had been diagnosed by experienced allergists. All included patients who answered a questionnaire regarding seasonal pollinosis and clinical symptoms after ingestion of food and underwent intradermal skin tests. Total IgE and specific IgE levels were quantified by ImmunoCAP, using 0.35 kUA/L as a threshold for positivity. Results: The patients were divided into 3 groups, based on the season during which they experienced symptoms and the 2 peaks of Chinese airborne pollen: spring-tree pollen symptoms group (SG), autumn-weed pollen symptoms group (AG), and a combined spring and autumn pollen symptoms group (CG). Birch pollen (83%) and ash pollen (74%) were common allergens among patients with spring symptoms, while mugwort pollen (87%) was a common allergen among patients with autumn symptoms. In total, 30% of the study population experienced pollen-related food allergy. Pollen-related food allergies were more prevalent among the single-season symptom groups (68% and 50% for the SG and AG, respectively) than among the CG (20%). All patients with pollen-related food-induced anaphylaxis exhibited autumn weed pollen symptoms. Except for 2 patients, all patients with food-induced anaphylaxis were allergic to mugwort pollen. In the SG, all patients with food allergy were sensitive to birch pollen, with birch and Bet v 1-specific IgE levels higher in this group than in the group without food allergy (p < 0.001). In the AG, Art v 3 was more prevalent among patients with pollen-related food allergy than without food allergy (79% vs. 33%, p < 0.001), a proportion similar to the one in the CG (67% vs. 48%, p = 0.01). Meanwhile, the Art v 3-specific IgE levels among patients with pollen-related food allergy were higher than among tolerant patients in the AG (p < 0.001) and CG (p = 0.02). Unexpectedly, the Art v 3-specific IgE levels were higher in patients with food-induced anaphylaxis than with oral allergy syndrome only in the CG. Conclusions: Bet v 1 (a Pathogenesis-related 10 protein) and Art v 3 (a non-specific lipid transfer protein; nsLTP) are candidate molecular biomarkers for the diagnosis of food allergies in patients with season-specific pollen-related allergies. Measuring pollen allergen component-specific IgE levels might be an effective tool for the management of pollinosis in clinical practice in China.http://www.sciencedirect.com/science/article/pii/S1939455120300235PollinosisFood allergyAnaphylaxisBet v 1Art v 3 |
| spellingShingle | Jun-Da Li Zhi-Rong Du Juan Liu Ying-Yang Xu Rui-Qi Wang Jia Yin Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population World Allergy Organization Journal Pollinosis Food allergy Anaphylaxis Bet v 1 Art v 3 |
| title | Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population |
| title_full | Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population |
| title_fullStr | Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population |
| title_full_unstemmed | Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population |
| title_short | Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population |
| title_sort | characteristics of pollen related food allergy based on individual pollen allergy profiles in the chinese population |
| topic | Pollinosis Food allergy Anaphylaxis Bet v 1 Art v 3 |
| url | http://www.sciencedirect.com/science/article/pii/S1939455120300235 |
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