Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice

Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice

Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. D...

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Bibliographic Details
Main Authors: Nancy M. Lainez, Carrie R. Jonak, Meera G. Nair, Iryna M. Ethell, Emma H. Wilson, Monica J. Carson, Djurdjica Coss
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
sex-specific
cytokine
GnRH
neuroinflammation
obesity
hypothalamus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01992/full

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