Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort.
<h4>Background</h4>Alcohol drinking during pregnancy has been well-known to cause the detrimental effects on fetal development; however, the adverse effects of pre-pregnancy drinking are largely unknown. We investigate whether alcohol drinking status before pregnancy is associated with t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0271291 |
| _version_ | 1818017364055162880 |
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| author | Seul Koo Ji Yeon Kim Ji Hye Park Gu Seob Roh Nam Kyoo Lim Hyun Young Park Won-Ho Kim |
| author_facet | Seul Koo Ji Yeon Kim Ji Hye Park Gu Seob Roh Nam Kyoo Lim Hyun Young Park Won-Ho Kim |
| author_sort | Seul Koo |
| collection | DOAJ |
| description | <h4>Background</h4>Alcohol drinking during pregnancy has been well-known to cause the detrimental effects on fetal development; however, the adverse effects of pre-pregnancy drinking are largely unknown. We investigate whether alcohol drinking status before pregnancy is associated with the risk for macrosomia, an offspring's adverse outcome, in a Korean pregnancy registry cohort (n = 4,542) enrolled between 2013 and 2017.<h4>Methods</h4>Binge drinking was defined as consuming ≥5 drinks on one occasion and ≥2 times a week, and a total 2,886 pregnant, included in the final statistical analysis, were divided into 3 groups: never, non-binge, and binge drinking.<h4>Results</h4>The prevalence of macrosomia was higher in binge drinking before pregnancy than those with never or non-binge drinking (7.5% vs. 3.2% or 2.9%, p = 0.002). Multivariable logistic regression analysis demonstrated an independent association between macrosomia and prepregnancy binge drinking after adjusting for other confounders (adjusted odds ratio = 2.29; 95% CI, 1.08-4.86; p = 0.031). The model added binge drinking before pregnancy led to improvement of 10.6% (95% CI, 2.03-19.07; p = 0.0006) in discrimination from traditional risk prediction models.<h4>Conclusion</h4>Together, binge drinking before pregnancy might be an independent risk factor for developing macrosomia. Intensified intervention for drinking alcohol in women who are planning a pregnancy is important and may help prevent macrosomia. |
| first_indexed | 2024-04-14T07:26:05Z |
| format | Article |
| id | doaj.art-06a374b2898040668225092ef8927a46 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:26:05Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-06a374b2898040668225092ef8927a462022-12-22T02:06:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e027129110.1371/journal.pone.0271291Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort.Seul KooJi Yeon KimJi Hye ParkGu Seob RohNam Kyoo LimHyun Young ParkWon-Ho Kim<h4>Background</h4>Alcohol drinking during pregnancy has been well-known to cause the detrimental effects on fetal development; however, the adverse effects of pre-pregnancy drinking are largely unknown. We investigate whether alcohol drinking status before pregnancy is associated with the risk for macrosomia, an offspring's adverse outcome, in a Korean pregnancy registry cohort (n = 4,542) enrolled between 2013 and 2017.<h4>Methods</h4>Binge drinking was defined as consuming ≥5 drinks on one occasion and ≥2 times a week, and a total 2,886 pregnant, included in the final statistical analysis, were divided into 3 groups: never, non-binge, and binge drinking.<h4>Results</h4>The prevalence of macrosomia was higher in binge drinking before pregnancy than those with never or non-binge drinking (7.5% vs. 3.2% or 2.9%, p = 0.002). Multivariable logistic regression analysis demonstrated an independent association between macrosomia and prepregnancy binge drinking after adjusting for other confounders (adjusted odds ratio = 2.29; 95% CI, 1.08-4.86; p = 0.031). The model added binge drinking before pregnancy led to improvement of 10.6% (95% CI, 2.03-19.07; p = 0.0006) in discrimination from traditional risk prediction models.<h4>Conclusion</h4>Together, binge drinking before pregnancy might be an independent risk factor for developing macrosomia. Intensified intervention for drinking alcohol in women who are planning a pregnancy is important and may help prevent macrosomia.https://doi.org/10.1371/journal.pone.0271291 |
| spellingShingle | Seul Koo Ji Yeon Kim Ji Hye Park Gu Seob Roh Nam Kyoo Lim Hyun Young Park Won-Ho Kim Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort. PLoS ONE |
| title | Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort. |
| title_full | Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort. |
| title_fullStr | Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort. |
| title_full_unstemmed | Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort. |
| title_short | Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort. |
| title_sort | binge alcohol drinking before pregnancy is closely associated with the development of macrosomia korean pregnancy registry cohort |
| url | https://doi.org/10.1371/journal.pone.0271291 |
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